On the dimorphism and the pressure-temperature state diagram of racemic m-nisoldipine, a dihydropyridine calcium ion antagonist.
Ann Pharm Fr
; 76(5): 341-347, 2018 Sep.
Article
en En
| MEDLINE
| ID: mdl-29798781
The pressure-temperature phase diagram of the dimorphism of racemic m-nisoldipine is constructed using temperatures and enthalpies of fusion of forms A and B. At ordinary pressure, the transition from form B to form A is found to occur around 192K, which indicates that these polymorphs are enantiotropically related and that form A is stable at room temperature. Nevertheless, the phase relationship turns to be monotropic when pressures become greater than about 100MPa, which indicates that form B becomes the sole stable phase.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bloqueadores de los Canales de Calcio
/
Nisoldipino
Idioma:
En
Revista:
Ann Pharm Fr
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia