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Mechanisms of Antiviral Activity of the Polyphenol Complex from Seagrass of the Zosteraceae Family against Tick-Borne Encephalitis Virus.
Krylova, N V; Leonova, G N; Maystrovskaya, O S; Popov, A M; Artyukov, A A.
Afiliación
  • Krylova NV; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia. krylovanatalya@gmail.com.
  • Leonova GN; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
  • Maystrovskaya OS; G. P. Somov Research Institute of Epidemiology and Microbiology, Vladivostok, Russia.
  • Popov AM; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science, Vladivostok, Russia.
  • Artyukov AA; G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Division of the Russian Academy of Science, Vladivostok, Russia.
Bull Exp Biol Med ; 165(1): 61-63, 2018 May.
Article en En | MEDLINE | ID: mdl-29797124
Antiviral activity of the polyphenol complex from seagrass of the Zosteraceae family against highly pathogenic strain of the tick-borne encephalitis virus was studied on passaged culture of porcine embryo kidney cells. The antiviral effect of the test compound manifested in a decrease in the infectious titer of the virus and depended on the concentration and application schemes. Polyphenol complex in a concentration of 100 µg/ml suppressed accumulation of the pathogen in the cell culture: pretreatment of the virus reduced its titer by 4 log, pretreatment of cells by 1.4 log, and application of the compound 1 h after cell infection by 2.8 log. Antiviral action of the test compound is determined by direct inactivation of the virus and inhibition of virus replication at the early stage, which attests to potential of this compound in the treatment of tick-borne encephalitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Zosteraceae / Virus de la Encefalitis Transmitidos por Garrapatas / Polifenoles Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Zosteraceae / Virus de la Encefalitis Transmitidos por Garrapatas / Polifenoles Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos