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KLF4 Mediates the Effect of 5-ASA on the ß-Catenin Pathway in Colon Cancer Cells.
Parenti, Sandra; Montorsi, Lucia; Fantini, Sebastian; Mammoli, Fabiana; Gemelli, Claudia; Atene, Claudio Giacinto; Losi, Lorena; Frassineti, Chiara; Calabretta, Bruno; Tagliafico, Enrico; Ferrari, Sergio; Zanocco-Marani, Tommaso; Grande, Alexis.
Afiliación
  • Parenti S; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Montorsi L; Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy.
  • Fantini S; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Mammoli F; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Gemelli C; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Atene CG; Science and Technology Park for Medicine, Mirandola, Modena, Italy.
  • Losi L; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Frassineti C; Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Calabretta B; Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Tagliafico E; Department of Clinical and Diagnostic Medicine and Public Health, University of Modena and Reggio Emilia, Modena, Italy.
  • Ferrari S; Department of Cancer Biology and SKKC, Thomas Jefferson University, Philadelphia, Pennsylvania.
  • Zanocco-Marani T; Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy.
  • Grande A; Center for Genome Research, University of Modena and Reggio Emilia, Modena, Italy.
Cancer Prev Res (Phila) ; 11(8): 503-510, 2018 08.
Article en En | MEDLINE | ID: mdl-29794245
Mesalazine (5-ASA) is an aminosalicylate anti-inflammatory drug capable of inducing µ-protocadherin, a protein expressed by colorectal epithelial cells that is downregulated upon malignant transformation. Treatment with 5-ASA restores µ-protocadherin expression and promotes the sequestration of ß-catenin to the plasma membrane. Here, we show that 5-ASA-induced µ-protocadherin expression is directly regulated by the KLF4 transcription factor. In addition, we suggest the existence of a dual mechanism whereby 5-ASA-mediated ß-catenin inhibition is caused by µ-protocadherin-dependent sequestration of ß-catenin to the plasma membrane and by the direct binding of KLF4 to ß-catenin. In addition, we found that 5-ASA treatment suppresses the expression of miR-130a and miR-135b, which target KLF4 mRNA, raising the possibility that this mechanism is involved in the increased expression of KLF4 induced by 5-ASA. Cancer Prev Res; 11(8); 503-10. ©2018 AACR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Neoplasias del Colon / Mesalamina / Factores de Transcripción de Tipo Kruppel / Vía de Señalización Wnt Límite: Humans Idioma: En Revista: Cancer Prev Res (Phila) Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antiinflamatorios no Esteroideos / Neoplasias del Colon / Mesalamina / Factores de Transcripción de Tipo Kruppel / Vía de Señalización Wnt Límite: Humans Idioma: En Revista: Cancer Prev Res (Phila) Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos