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Calciprotein Particle Formation in Peritoneal Dialysis Effluent Is Dependent on Dialysate Calcium Concentration.
Cai, Michael M X; Smith, Edward R; Kent, Annette; Huang, Louis; Hewitson, Timothy D; McMahon, Lawrence P; Holt, Stephen G.
Afiliación
  • Cai MMX; Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Australia Michael.cai@mh.org.au.
  • Smith ER; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia.
  • Kent A; Department of Nephrology, The Royal Melbourne Hospital, Melbourne, Australia.
  • Huang L; Department of Medicine (Royal Melbourne Hospital), University of Melbourne, Melbourne, Australia.
  • Hewitson TD; Eastern Health Integrated Renal Services, Eastern Health, Melbourne, Australia.
  • McMahon LP; Eastern Health Integrated Renal Services, Eastern Health, Melbourne, Australia.
  • Holt SG; Eastern Health Clinical School, Monash University, Melbourne, Australia.
Perit Dial Int ; 38(4): 286-292, 2018.
Article en En | MEDLINE | ID: mdl-29793980
BACKGROUND: The accumulation of fetuin-A-containing calciprotein particles (CPP) in the serum of patients with renal disease and those with chronic inflammation may be involved in driving sterile inflammation and extraosseous mineral deposition. We previously showed that both fetuin-A and CPP were present in the peritoneal dialysis (PD) effluent of stable PD patients. It is unknown whether different PD fluids might affect the formation of CPP in vivo. METHOD: Peritoneal effluent from 12 patients was collected after a 6-hour dwell with 7 different commercial PD fluids. Calciprotein particles and inflammatory cytokines were measured by flow cytometry. RESULTS: High inter-subject variability in CPP concentration was observed. Peritoneal dialysis fluids containing 1.75 mmol/L calcium were associated with enhanced formation of CPP in vivo, compared with fluids containing 1.25 mmol/L calcium. Osmotic agent, fluid pH, and glucose concentration did not affect CPP formation. Peritoneal dialysis effluent CPP levels were not associated with changes in inflammatory cytokines. CONCLUSION: High calcium-containing PD fluids favor intraperitoneal CPP formation. This finding may have relevance for future PD fluid design.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Soluciones para Diálisis / Calcio / Diálisis Peritoneal / Nanopartículas Calcificantes / Alfa-2-Glicoproteína-HS / Fallo Renal Crónico Tipo de estudio: Etiology_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Perit Dial Int Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Soluciones para Diálisis / Calcio / Diálisis Peritoneal / Nanopartículas Calcificantes / Alfa-2-Glicoproteína-HS / Fallo Renal Crónico Tipo de estudio: Etiology_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Perit Dial Int Asunto de la revista: NEFROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos