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Functionalized silk fibers from transgenic silkworms for wound healing applications: Surface presentation of bioactive epidermal growth factor.
Wöltje, Michael; Böbel, Melanie; Bienert, Michaela; Neuss, Sabine; Aibibu, Dilibaier; Cherif, Chokri.
Afiliación
  • Wöltje M; Institute of Textile Machinery and High Performance Material Technology, TU Dresden, Hohe Str. 6, Dresden, 01069, Germany.
  • Böbel M; Institute of Textile Machinery and High Performance Material Technology, TU Dresden, Hohe Str. 6, Dresden, 01069, Germany.
  • Bienert M; Institute of Pathology & Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany.
  • Neuss S; Institute of Pathology & Helmholtz Institute for Biomedical Engineering, Biointerface Group, RWTH Aachen University, Pauwelsstr. 30, Aachen, 52074, Germany.
  • Aibibu D; Institute of Textile Machinery and High Performance Material Technology, TU Dresden, Hohe Str. 6, Dresden, 01069, Germany.
  • Cherif C; Institute of Textile Machinery and High Performance Material Technology, TU Dresden, Hohe Str. 6, Dresden, 01069, Germany.
J Biomed Mater Res A ; 106(10): 2643-2652, 2018 10.
Article en En | MEDLINE | ID: mdl-29790257
Growth factors play a crucial role in wound healing in general and are promising tools for the treatment of chronic wounds as they can restore the physiological wound healing process. In growth factor-loaded wound dressings, human epidermal growth factor (EGF) is released in a burst and washed out quickly. The developed matrix consists of recombinant EGF produced in transgenic silkworms as a fusion protein with the fibroin light chain. The covalent linkage prevents EGF from draining into the surrounding tissue while presenting the growth factor on the surface. EGF-functionalized silk membranes and nonwovens lead to a 2.5-fold increase in the cell number of fibroblasts, while retaining full bioactivity even after e-beam sterilization. EGF is long-term presented without burst release and significantly reduces the wound area by 15% in an in vitro wound model. Hence, the cost-effective production of a biomaterial using transgenic silkworm larvae in combination with a growth factor paves the way for a promising new multifactorial wound cover for chronic wound healing. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2643-2652, 2018.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombyx / Cicatrización de Heridas / Seda / Factor de Crecimiento Epidérmico Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bombyx / Cicatrización de Heridas / Seda / Factor de Crecimiento Epidérmico Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos