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Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control.
Bing, Chenchen; Hong, Yu; Hernandez, Christopher; Rich, Megan; Cheng, Bingbing; Munaweera, Imalka; Szczepanski, Debra; Xi, Yin; Bolding, Mark; Exner, Agata; Chopra, Rajiv.
Afiliación
  • Bing C; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA. chenchen.bing@utsouthwestern.edu.
  • Hong Y; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Hernandez C; Department of Radiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
  • Rich M; Division of Advanced Medical Imaging Research, University of Alabama, Birmingham, AL, 35294, USA.
  • Cheng B; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Munaweera I; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Szczepanski D; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Xi Y; Department of Radiology, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Bolding M; Department of Clinical Science, UT Southwestern Medical Center, Dallas, TX, 75390, USA.
  • Exner A; Division of Advanced Medical Imaging Research, University of Alabama, Birmingham, AL, 35294, USA.
  • Chopra R; Department of Radiology, Case Western Reserve University, Cleveland, OH, 44106, USA.
Sci Rep ; 8(1): 7986, 2018 05 22.
Article en En | MEDLINE | ID: mdl-29789589
Focused ultrasound combined with bubble-based agents serves as a non-invasive way to open the blood-brain barrier (BBB). Passive acoustic detection was well studied recently to monitor the acoustic emissions induced by the bubbles under ultrasound energy, but the ability to perform reliable BBB opening with a real-time feedback control algorithm has not been fully evaluated. This study focuses on characterizing the acoustic emissions of different types of bubbles: Optison, Definity, and a custom-made nanobubble. Their performance on reliable BBB opening under real-time feedback control based on acoustic detection was evaluated both in-vitro and in-vivo. The experiments were conducted using a 0.5 MHz focused ultrasound transducer with in-vivo focal pressure ranges from 0.1-0.7 MPa. Successful feedback control was achieved with all three agents when combining with infusion injection. Localized opening was confirmed with Evans blue dye leakage. Microscopic images were acquired to review the opening effects. Under similar total gas volume, nanobubble showed a more reliable opening effect compared to Optison and Definity (p < 0.05). The conclusions obtained from this study confirm the possibilities of performing stable opening using a feedback control algorithm combined with infusion injection. It also opens another potential research area of BBB opening using sub-micron bubbles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sonicación / Encéfalo / Barrera Hematoencefálica / Microburbujas / Composición de Medicamentos Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sonicación / Encéfalo / Barrera Hematoencefálica / Microburbujas / Composición de Medicamentos Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido