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Feline injection site sarcoma: immunohistochemical characteristics.
Carneiro, Carolina S; de Queiroz, Genilson F; Pinto, Ana Cbcf; Dagli, Maria Lz; Matera, Julia M.
Afiliación
  • Carneiro CS; 1 Department of Veterinary Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • de Queiroz GF; 2 Department of Animal Science, Federal Rural University of Semi-Arid, Mossoró, Brazil.
  • Pinto AC; 1 Department of Veterinary Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • Dagli ML; 3 Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
  • Matera JM; 1 Department of Veterinary Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, Brazil.
J Feline Med Surg ; 21(4): 314-321, 2019 04.
Article en En | MEDLINE | ID: mdl-29788832
OBJECTIVES: Feline injection site sarcoma (FISS) is a rapid growing locally aggressive tumor with a low metastatic rate. Its histologic features are clearly defined, but there are few studies regarding its immunohistochemical characteristics. The present study investigated the immunohistochemical characteristics of 21 cases of FISS. METHODS: FISSs from 12 male and nine female cats, 20 mixed-breed and one Siamese, were included in the study. After histopathological diagnosis, additional histologic sections were immunostained for vimentin, cytokeratin, desmin, S100 protein, viral feline leukemia virus (FeLV) particles, cyclooxygenase 2 (COX-2) and c-KIT. Positive and negative controls were adopted accordingly. Immunostainings were classified as positive or negative according to the number of positive cells from a total of 1000 cells per tumor section. RESULTS: Histopathologic diagnosis of the tumors revealed 18 (85.7%) fibrosarcomas and three (14.3%) other sarcomas; four fibrosarcomas (22.2%) were grade III, five (27.8%) were grade II and nine (50.0%) were grade I. Two sarcomas were grade III and one was grade II. Seventeen (81%) tumors were negative for desmin. All samples were positive for vimentin. Twenty tumors (95.2%) were positive for S-100 protein. Positivity for c-KIT was observed in four (19%) samples; COX-2 was positive in 13 (61.9%) and FeLV viral particles were positive in nine (42.9%) FISSs. CONCLUSIONS AND RELEVANCE: Immunohistochemical findings of FISSs revealed positive immunostainings for desmin, vimentin, S-100 protein, c-KIT, COX-2 and FeLV viral particles.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Enfermedades de los Gatos / Reacción en el Punto de Inyección Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Feline Med Surg Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Enfermedades de los Gatos / Reacción en el Punto de Inyección Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Feline Med Surg Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido