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The developmental-genetics of canalization.
Hallgrimsson, Benedikt; Green, Rebecca M; Katz, David C; Fish, Jennifer L; Bernier, Francois P; Roseman, Charles C; Young, Nathan M; Cheverud, James M; Marcucio, Ralph S.
Afiliación
  • Hallgrimsson B; Dept. of Cell Biology & Anatomy, Alberta Children's Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada. Electronic address: bhallgri@ucalgary.ca.
  • Green RM; Dept. of Cell Biology & Anatomy, Alberta Children's Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
  • Katz DC; Dept. of Cell Biology & Anatomy, Alberta Children's Hospital Research Institute and McCaig Bone and Joint Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
  • Fish JL; Dept. of Biological Sciences, University of Massachusetts Lowell, Lowell, MA, 01854, USA.
  • Bernier FP; Dept of Medical Genetics, Alberta Children's Hospital Research Institute Cumming School of Medicine, University of Calgary, Calgary, AB, T2N 4N1, Canada.
  • Roseman CC; Dept. of Animal Biology, University of Illinois Urbana Champaign, Urbana, IL, 61801, USA.
  • Young NM; Dept. of Orthopaedic Surgery, School of Medicine, University of California San Francisco, San Francisco, CA, 94110, USA.
  • Cheverud JM; Dept. of Biology, Loyola University Chicago, Chicago, IL, 60660, USA.
  • Marcucio RS; Dept. of Orthopaedic Surgery, School of Medicine, University of California San Francisco, San Francisco, CA, 94110, USA. Electronic address: Ralph.Marcucio@ucsf.edu.
Semin Cell Dev Biol ; 88: 67-79, 2019 04.
Article en En | MEDLINE | ID: mdl-29782925
Canalization, or robustness to genetic or environmental perturbations, is fundamental to complex organisms. While there is strong evidence for canalization as an evolved property that varies among genotypes, the developmental and genetic mechanisms that produce this phenomenon are very poorly understood. For evolutionary biology, understanding how canalization arises is important because, by modulating the phenotypic variation that arises in response to genetic differences, canalization is a determinant of evolvability. For genetics of disease in humans and for economically important traits in agriculture, this subject is important because canalization is a potentially significant cause of missing heritability that confounds genomic prediction of phenotypes. We review the major lines of thought on the developmental-genetic basis for canalization. These fall into two groups. One proposes specific evolved molecular mechanisms while the other deals with robustness or canalization as a more general feature of development. These explanations for canalization are not mutually exclusive and they overlap in several ways. General explanations for canalization are more likely to involve emergent features of development than specific molecular mechanisms. Disentangling these explanations is also complicated by differences in perspectives between genetics and developmental biology. Understanding canalization at a mechanistic level will require conceptual and methodological approaches that integrate quantitative genetics and developmental biology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Epigénesis Genética / Epistasis Genética / Evolución Biológica / Estudios de Asociación Genética / Genotipo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenotipo / Epigénesis Genética / Epistasis Genética / Evolución Biológica / Estudios de Asociación Genética / Genotipo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Cell Dev Biol Asunto de la revista: EMBRIOLOGIA Año: 2019 Tipo del documento: Article Pais de publicación: Reino Unido