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Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy.
Witkin, J M; Smith, J L; Ping, X; Gleason, S D; Poe, M M; Li, G; Jin, X; Hobbs, J; Schkeryantz, J M; McDermott, J S; Alatorre, A I; Siemian, J N; Cramer, J W; Airey, D C; Methuku, K R; Tiruveedhula, V V N P B; Jones, T M; Crawford, J; Krambis, M J; Fisher, J L; Cook, J M; Cerne, R.
Afiliación
  • Witkin JM; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA. Electronic address: witkinconsult@gmail.com.
  • Smith JL; Indiana University/Purdue University, Riley Hospital, Indianapolis, IN, USA.
  • Ping X; Indiana University/Purdue University, Riley Hospital, Indianapolis, IN, USA.
  • Gleason SD; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Poe MM; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Li G; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Jin X; Indiana University/Purdue University, Riley Hospital, Indianapolis, IN, USA.
  • Hobbs J; Indiana University/Purdue University, Riley Hospital, Indianapolis, IN, USA.
  • Schkeryantz JM; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • McDermott JS; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Alatorre AI; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Siemian JN; Department of Pharmacology, Physiology & Neuroscience, School of Medicine, University of South Carolina, Columbia, SC, USA.
  • Cramer JW; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Airey DC; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Methuku KR; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Tiruveedhula VVNPB; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Jones TM; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Crawford J; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Krambis MJ; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA.
  • Fisher JL; Department of Pharmacology, Physiology & Neuroscience, School of Medicine, University of South Carolina, Columbia, SC, USA.
  • Cook JM; Department of Chemistry & Biochemistry, University of Wisconsin-Milwaukee, Milwaukee, WI, USA.
  • Cerne R; The Lilly Research Labs, Eli Lilly and Company, Indianapolis, IN, USA. Electronic address: rok_cerne@yahoo.com.
Neuropharmacology ; 137: 332-343, 2018 07 15.
Article en En | MEDLINE | ID: mdl-29778948
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazoles / Convulsiones / Agonistas de Receptores de GABA-A / Anticonvulsivantes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Neuropharmacology Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxazoles / Convulsiones / Agonistas de Receptores de GABA-A / Anticonvulsivantes Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Animals / Child / Female / Humans / Male Idioma: En Revista: Neuropharmacology Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido