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Improving the oral bioavailability of tapentadol via a carbamate prodrug approach: synthesis, bioactivation, and pharmacokinetics.
Li, Yingchao; Wang, Yongjun; Zhang, Ran; Liu, Cuiru; Wei, Yue; Sun, Jin; He, Zhonggui; Xu, Youjun; Zhang, Tianhong.
Afiliación
  • Li Y; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 120 Mailbox, 103 Wenhua Road, Shenyang, 110016, China.
  • Wang Y; Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
  • Zhang R; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 120 Mailbox, 103 Wenhua Road, Shenyang, 110016, China.
  • Liu C; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 120 Mailbox, 103 Wenhua Road, Shenyang, 110016, China.
  • Wei Y; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 120 Mailbox, 103 Wenhua Road, Shenyang, 110016, China.
  • Sun J; Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
  • He Z; Department of Biopharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China.
  • Xu Y; Department of Pharmaceutical Analysis, School of Pharmacy, Shenyang Pharmaceutical University, No. 120 Mailbox, 103 Wenhua Road, Shenyang, 110016, China. xuyoujun@syphu.edu.cn.
  • Zhang T; Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang, 110016, China. xuyoujun@syphu.edu.cn.
Drug Deliv Transl Res ; 8(5): 1335-1344, 2018 10.
Article en En | MEDLINE | ID: mdl-29777509
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamatos / Profármacos / Tapentadol Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Drug Deliv Transl Res Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carbamatos / Profármacos / Tapentadol Tipo de estudio: Qualitative_research Límite: Animals Idioma: En Revista: Drug Deliv Transl Res Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos