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Contrasting patterns of RUNX2 repeat variations are associated with palate shape in phyllostomid bats and New World primates.
Ferraz, Tiago; Rossoni, Daniela M; Althoff, Sérgio L; Pissinatti, Alcides; Paixão-Cortês, Vanessa R; Bortolini, Maria Cátira; González-José, Rolando; Marroig, Gabriel; Salzano, Francisco M; Gonçalves, Gislene L; Hünemeier, Tábita.
Afiliación
  • Ferraz T; Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, 91501-970, Porto Alegre, RS, Brazil.
  • Rossoni DM; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, 05508-900, São Paulo, SP, Brazil.
  • Althoff SL; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, 05508-900, São Paulo, SP, Brazil.
  • Pissinatti A; Regional University of Blumenau, Blumenau, SC, Brazil.
  • Paixão-Cortês VR; Biology Department, Federal University of Bahia, Salvador, BA, Brazil.
  • Bortolini MC; Rio de Janeiro Primatology Center, 20940-200, Rio de Janeiro, RJ, Brazil.
  • González-José R; Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, 91501-970, Porto Alegre, RS, Brazil.
  • Marroig G; Patagonian Institute of Social and Human Sciences, National Council for Scientific and Technological Research-CONICET, U9120ACD, Puerto Madryn, Argentina.
  • Salzano FM; Department of Genetics and Evolutionary Biology, Biosciences Institute, University of São Paulo, 05508-900, São Paulo, SP, Brazil.
  • Gonçalves GL; Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, 91501-970, Porto Alegre, RS, Brazil.
  • Hünemeier T; Department of Genetics, Biosciences Institute, Federal University of Rio Grande do Sul, 91501-970, Porto Alegre, RS, Brazil.
Sci Rep ; 8(1): 7867, 2018 05 18.
Article en En | MEDLINE | ID: mdl-29777172
Establishing the genetic basis that underlies craniofacial variability in natural populations is one of the main topics of evolutionary and developmental studies. One of the genes associated with mammal craniofacial variability is RUNX2, and in the present study we investigated the association between craniofacial length and width and RUNX2 across New World bats (Phyllostomidae) and primates (Catarrhini and Platyrrhini). Our results showed contrasting patterns of association between the glutamate/alanine ratios (Q/A ratio) and palate shape in these highly diverse groups. In phyllostomid bats, we found an association between shorter/broader faces and increase of the Q/A ratio. In New World monkeys (NWM) there was a positive correlation of increasing Q/A ratios to more elongated faces. Our findings reinforced the role of the Q/A ratio as a flexible genetic mechanism that would rapidly change the time of skull ossification throughout development. However, we propose a scenario in which the influence of this genetic adjustment system is indirect. The Q/A ratio would not lead to a specific phenotype, but throughout the history of a lineage, would act along with evolutionary constraints, as well as other genes, as a facilitator for adaptive morphological changes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hueso Paladar / Quirópteros / Platirrinos / Subunidad alfa 1 del Factor de Unión al Sitio Principal Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hueso Paladar / Quirópteros / Platirrinos / Subunidad alfa 1 del Factor de Unión al Sitio Principal Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido