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Multispectral-Fluorescence Imaging as a Tool to Separate Healthy from Disease-Related Lymphatic Anatomy During Robot-Assisted Laparoscopy.
Meershoek, Philippa; KleinJan, Gijs H; van Oosterom, Matthias N; Wit, Esther M K; van Willigen, Danny M; Bauwens, Kevin P; van Gennep, Erik J; Mottrie, Alexandre M; van der Poel, Henk G; van Leeuwen, Fijs W B.
Afiliación
  • Meershoek P; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • KleinJan GH; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  • van Oosterom MN; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Wit EMK; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  • van Willigen DM; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Bauwens KP; Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
  • van Gennep EJ; Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands.
  • Mottrie AM; Orsi Academy, Melle, Belgium.
  • van der Poel HG; Department of Urology, Leiden University Medical Center, Leiden, The Netherlands; and.
  • van Leeuwen FWB; Orsi Academy, Melle, Belgium.
J Nucl Med ; 59(11): 1757-1760, 2018 11.
Article en En | MEDLINE | ID: mdl-29777008
To reduce the invasive nature of extended pelvic lymph node (LN) dissections in prostate cancer, we have developed a multispectral-fluorescence guidance approach that enables discrimination between prostate-draining LNs and lower-limb-draining LNs. Methods: In 5 pigs, multispectral-fluorescence guidance was used on da Vinci Si and da Vinci Xi robots. The animals received fluorescein into the lower limb and indocyanine green-nanocolloid into the prostate. Results: Fluorescein was detected in 29 LNs (average of 3.6 LNs/template), and indocyanine green-nanocolloid was detected in 12 LNs (average of 1.2 LNs/template). Signal intensities appeared equal for both dyes, and no visual overlap in lymphatic drainage patterns was observed. Furthermore, fluorescein supported both the identification of leakage from damaged lymphatic structures and the identification of ureters. Conclusion: We demonstrated that the differences in lymphatic flow pattern between the prostate and lower limbs could be intraoperatively distinguished using multispectral-fluorescence imaging.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cirugía Asistida por Computador / Imagen Óptica / Procedimientos Quirúrgicos Robotizados / Escisión del Ganglio Linfático Límite: Animals / Humans / Male Idioma: En Revista: J Nucl Med Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cirugía Asistida por Computador / Imagen Óptica / Procedimientos Quirúrgicos Robotizados / Escisión del Ganglio Linfático Límite: Animals / Humans / Male Idioma: En Revista: J Nucl Med Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos