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Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair.
Zeeshan, Rabia; Mutahir, Zeeshan; Iqbal, Haffsah; Ali, Moazzam; Iqbal, Farasat; Ijaz, Kashif; Sharif, Faiza; Shah, Asma Tufail; Chaudhry, Aqif Anwar; Yar, Muhammad; Luan, Shifang; Khan, Ather Farooq.
Afiliación
  • Zeeshan R; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Mutahir Z; Institute of Biochemistry and Biotechnology, University of the Punjab, 54590 Lahore, Pakistan.
  • Iqbal H; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Ali M; Institute of Biochemistry and Biotechnology, University of the Punjab, 54590 Lahore, Pakistan.
  • Iqbal F; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Ijaz K; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Sharif F; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Shah AT; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Chaudhry AA; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Yar M; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan.
  • Luan S; State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
  • Khan AF; Interdisciplinary Research Centre in Biomedical Materials, COMSATS Institute of Information Technology, Defence Road, Off. Raiwind Road, Lahore, 54000, Pakistan. Electronic address: atherfarooq@ciitlahore.edu.pk.
  • Ihtesham-Ur-Rehman; The Kroto Research Institute, North Campus, University of Sheffield,Broad Lane, Sheffield, S3 7HQ, UK.
Carbohydr Polym ; 193: 9-18, 2018 Aug 01.
Article en En | MEDLINE | ID: mdl-29773402
The success of a dental implant relies on the presence of an optimal alveolar ridge. The aim of this study was to fabricate HPMC crosslinked chitosan based scaffolds for alveolar bone repair. Our results indicated that HPMC crosslinked CH/BG foams presented better morphological structure (132-90.5 µm) and mechanical responses (0.451 MPa with 100 mg BG) as confirmed by SEM analysis and fatigue testing respectively. Cytotoxicity analysis at day 2, 4 and 8 demonstrated that all composites were non-toxic and supported cellular viability. Calcein AM/propidium iodide staining, Hoechst nuclear staining and cell adhesion assay reiterated that scaffolds supported pre-osteoblast cell growth, adhesion and proliferation. Differentiation potential of pre-osteoblast cells was enhanced as confirmed by alkaline phosphate assay. Furthermore, loss of S. aureus viability as low as 35% was attributed to synergistic effects of components. Overall, our results suggest that HPMC crosslinked scaffolds are potential candidates for alveolar bone repair.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Regeneración Ósea / Trasplante Óseo / Reactivos de Enlaces Cruzados / Quitosano / Derivados de la Hipromelosa Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2018 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxido de Zinc / Regeneración Ósea / Trasplante Óseo / Reactivos de Enlaces Cruzados / Quitosano / Derivados de la Hipromelosa Límite: Animals Idioma: En Revista: Carbohydr Polym Año: 2018 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Reino Unido