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Effect of highly concentrated hyaluronic acid/chondroitin sulphate instillation on ureteric stent-induced discomfort after ureteroscopic lithotripsy: a multicentre randomised controlled pilot study.
Jo, Jung Ki; Kim, Jae Heon; Kim, Kyu Shik; Chung, Jae Hoon; Kim, Yong Tae; Choi, Hong Yong; Song, Eun-Seop; Lee, Bora; Lee, Seung Wook.
Afiliación
  • Jo JK; Department of Urology, Hanyang University Seoul Hospital, Seoul, Korea.
  • Kim JH; Department of Urology, Soonchunhyang University Hospital, Soonchunhyang University Medical College, Seoul, Korea.
  • Kim KS; Department of Urology, Hanyang University Guri Hospital, Guri, Korea.
  • Chung JH; Department of Urology, Hanyang University Seoul Hospital, Seoul, Korea.
  • Kim YT; Department of Urology, Hanyang University Seoul Hospital, Seoul, Korea.
  • Choi HY; Department of Urology, Hanyang University Guri Hospital, Guri, Korea.
  • Song ES; Department of Obstetrics and Gynecology, Inha University School of Medicine, Incheon, Korea.
  • Lee B; Department of Biostatistics, Clinical Trial Center, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
  • Lee SW; Department of Urology, Hanyang University Guri Hospital, Guri, Korea.
BJU Int ; 122(5): 858-865, 2018 11.
Article en En | MEDLINE | ID: mdl-29772114
OBJECTIVE: To investigate the effectiveness and safety of instilling highly concentrated hyaluronic acid (HA)/chondroitin sulphate (CS) on ureteric stent-related pain, urinary symptoms, and quality of life (QoL) of patients who underwent ureteroscopic lithotripsy for ureteric stones followed by ureteric stent placement. PATIENTS AND METHODS: Eligible patients were randomly allocated to receive intravesical instillation with HA/CS or normal saline just after ureteric stent placement. Just before stent removal on postoperative day 7, the patients completed the Ureteric Stent Symptom Questionnaire (USSQ), International Prostate Symptom Score (IPSS) QoL question, and a pain visual analogue scale (VAS). RESULTS: In total, 92 patients (46 each in the treatment and control arms) completed the study. The groups did not differ in terms of age or stent indwelling time. Compared with the control group, the treatment group had significantly lower USSQ urinary symptom domain scores (24.6 vs 32.5; P < 0.001), better IPSS QoL scores (3.5 vs 4.4, P = 0.018), and lower VAS pain scores (2.0 vs 3.2; P < 0.001). They also had lower total body pain subscores (16.7 vs 22.0; P = 0.01) and lower additional pain subscores due to urinary tract infections (2.1 vs. 3.2; P = 0.01) in the USSQ. CONCLUSIONS: Highly concentrated HA/CS effectively improved urinary symptoms and pain, and reduced the need for additional medication or procedures after ureteric stent placement.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Litotricia / Stents / Sulfatos de Condroitina / Ureteroscopía / Ácido Hialurónico Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Postoperatorio / Litotricia / Stents / Sulfatos de Condroitina / Ureteroscopía / Ácido Hialurónico Tipo de estudio: Clinical_trials Aspecto: Patient_preference Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: BJU Int Asunto de la revista: UROLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido