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Results of a real-world study on vortioxetine in patients with major depressive disorder in South East Asia (REVIDA).
Chin, Cheuk Ngen; Zain, Azhar; Hemrungrojn, Solaphat; Ung, Eng Khean; Kwansanit, Patanon; Au Yong, Koon Choong; Chong, Marvin Swee Woon; Inpa, Chalowat; Yen, Teck Hoe; Yeoh, Boon Beng David; Tay, Liam Kai; Bernardo, Carmina; Lim, Lionel Chee-Chong; Yap, Chin Hong; Fones, Calvin; Nayak, Ashwini; Nelleman, Lars.
Afiliación
  • Chin CN; a Klinik Pakar C N Chin Sdn Bhd, CMH Medical Center , Kuala Lumpur , Malaysia.
  • Zain A; b KPJ Ampang Puteri Specialist Hospital , Selangor , Malaysia.
  • Hemrungrojn S; c Chulalongkorn Hospital , Bangkok , Thailand.
  • Ung EK; d Adam Road Medical Centre, Singapore, Singapore.
  • Kwansanit P; e Somdejchaopraya Psychiatry Institute , Bangkok , Thailand.
  • Au Yong KC; f Klinik Pakar Au Yong , Kuala Lumpur , Malaysia.
  • Chong MSW; g Hospital Fatimah , Ipoh , Malaysia.
  • Inpa C; h Somdejphrachaotaksin Hospital , Muang Tak , Thailand.
  • Yen TH; i Neuropsy Clinic Sdn Bhd , Chinese Maternity Hospital , Kuala Lumpur , Malaysia.
  • Yeoh BBD; j Yeoh Psychiatric Clinic, Mahkota Medical Centre , Melaka , Malaysia.
  • Tay LK; k Dr Tay Liam Kai Psychiatric Care Clinic, Mount Elizabeth Novena Specialist Centre , Singapore , Singapore.
  • Bernardo C; l Mood and Anxiety Resource and Referral Center, Makati Medical Center , Makati , Philippines.
  • Lim LC; m L P Clinic Pte Ltd , Mount Elizabeth Medical Centre , Singapore , Singapore.
  • Yap CH; n Yap Psychiatry Specialist Clinic S/B , Kuching , Malaysia.
  • Fones C; o Fones Clinic, Gleneagles Medical Centre , Singapore , Singapore.
  • Nayak A; p Lundbeck Singapore Pte Ltd , Singapore.
  • Nelleman L; p Lundbeck Singapore Pte Ltd , Singapore.
Curr Med Res Opin ; 34(11): 1975-1984, 2018 11.
Article en En | MEDLINE | ID: mdl-29768955
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from August 2016 to April 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months. Depression severity was assessed using the PHQ-9 questionnaire (patient assessed) and CGI-S scale (physician assessed); cognitive function was assessed with the PDQ-D questionnaire; work productivity and activity impairment (WPAI) was assessed with the WPAI questionnaire. RESULTS: At baseline, 89.9% of patients were moderately to severely depressed (PHQ-9 score ≥10). During the 3 month treatment period, mean ± SD PHQ-9 score decreased from 18.7 ± 5.7 to 5.0 ± 5.3, mean ± SD CGI-S score decreased from 4.4 ± 0.7 to 2.2 ± 1.1 and mean ± SD PDQ-D score decreased from 42.1 ± 18.8 to 13.4 ± 13.0. By Month 3, response and remission rates reached 80.8% and 59.0%, respectively. Work productivity loss decreased from 73.6% to 30.5%, while activity impairment decreased from 71.5% to 24.6%. Positive correlations were observed between PHQ-9, PDQ-D, and WPAI work productivity loss and activity impairment. By Month 3, 82.0% of patients were either not depressed or only mildly depressed (PHQ-9 score ≤9). CONCLUSION: In real-world clinical settings, vortioxetine was effective in reducing depression severity and improving cognitive function and work productivity in SEA patients with major depression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Depresión / Trastorno Depresivo Mayor / Rendimiento Laboral / Vortioxetina Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Curr Med Res Opin Año: 2018 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cognición / Depresión / Trastorno Depresivo Mayor / Rendimiento Laboral / Vortioxetina Tipo de estudio: Diagnostic_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Curr Med Res Opin Año: 2018 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido