Trimetrexate: molecular structures and conformational similarities in two crystal forms.

Hempel, A; Camerman, N; Camerman, A

Hempel, A; Camerman, N; Camerman, A.

Afiliación

Hempel A; Department of Biochemistry, University of Toronto, Ontario, Canada.

Cancer Biochem Biophys ; 10(1): 25-30, 1988 Jul.

Article en En | MEDLINE | ID: mdl-2975964

RESUMEN

The structure of the non-classical quinazoline antifolate trimetrexate (TMQ) has been determined in two crystal forms, TMQ acetate monohydrate, and hydrated TMQ free base. Trimetrexate has an extended conformation in both structures, and the quinazoline and phenyl rings are mutually perpendicular. Protonation occurs at N1 in the acetate salt. The TMQ conformation is similar to corresponding parts of quinespar, the only other quinazoline antifolate structurally determined, and the hydrated strontium salt of methotrexate.

Asunto(s)

Antineoplásicos; Quinazolinas; Cristalización; Modelos Moleculares; Conformación Molecular; Trimetrexato

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinazolinas / Antineoplásicos Idioma: En Revista: Cancer Biochem Biophys Año: 1988 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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