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The role of miR-92b in cholangiocarcinoma patients.
Zhou, Min-Hang; Zhou, Hong-Wei; Liu, Mo; Sun, Jun-Zhong.
Afiliación
  • Zhou MH; Department of Geriatric Oncology, The First Affiliated Hospital of the People's Liberation Army General Hospital, Beijing, P.R. China.
  • Zhou HW; Department of Geriatric Oncology, The First Affiliated Hospital of the People's Liberation Army General Hospital, Beijing, P.R. China.
  • Liu M; Department of Geriatric Oncology, The First Affiliated Hospital of the People's Liberation Army General Hospital, Beijing, P.R. China.
  • Sun JZ; Department of Geriatric Oncology, The First Affiliated Hospital of the People's Liberation Army General Hospital, Beijing, P.R. China.
Int J Biol Markers ; 33(3): 293-300, 2018 Aug.
Article en En | MEDLINE | ID: mdl-29749758
PURPOSE: The role of microRNA (miRNA) in cholangiocarcinoma was not clear. The aim of this study was to find the potential diagnostic and prognostic miRNA in cholangiocarcinoma patients. METHODS: The miRNA expression profiles in cholangiocarcinoma patients from The Cancer Genome Atlas and Gene Expression Omnibus (GSE53870) were analyzed. The comparison of overall survival was performed using the Kaplan-Meier method. The targeted genes of prognostic miRNA were identified in miRanda, PicTar, or TargetScan, and their cell signaling pathways were analyzed by the Database for Annotation, Visualization and Integrated Discovery. RESULTS: In The Cancer Genome Atlas and the Gene Expression Omnibus miRNA dataset, miR-92b and miR-99a were found with concordant directionality, up-regulated and down-regulated, respectively. In The Cancer Genome Atlas survival data, patients with the high level of miR-99b had obviously shorter overall survival time ( P=0.038). However, the level of miR-99a was not found to be significant. The 17 shared target genes of miR-92b were identified, such as DAB21IP, BCL21L11, SPHK2, PER2, and TSC1. The related pathways included positive regulation of transcription, positive regulation of cellular biosynthetic process, regulation of programmed cell death, etc. Conclusion: miR-92b was up-regulated in cholangiocarcinoma compared with normal controls. The high level of miR-92b was associated with adverse outcomes in cholangiocarcinoma patients, which might be partly explained by the targeted genes of miR-92b and their signaling pathways.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Colangiocarcinoma / MicroARNs Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Biol Markers Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Colangiocarcinoma / MicroARNs Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Biol Markers Asunto de la revista: BIOQUIMICA / NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos