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Serum and Saliva Concentrations of Venlafaxine, O-Desmethylvenlafaxine, Quetiapine, and Citalopram in Psychiatric Patients.
Ebert, Katharina; Maurice, Elena; Lukacin, Richard; Fleischhaker, Christian; Schulz, Eberhard; Ebert, Dieter; Clement, Hans-Willi.
Afiliación
  • Ebert K; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg.
  • Maurice E; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg.
  • Lukacin R; Chromsystems Instruments & Chemicals GmbH, Gräfelfing. Dr. Lukacin is now with RECIPE Chemicals and Instruments GmbH, Munich, Germany.
  • Fleischhaker C; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg.
  • Schulz E; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg.
  • Ebert D; Department of Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg, Germany.
  • Clement HW; Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Centre for Mental Health, University Hospital of Freiburg, Freiburg.
Ther Drug Monit ; 40(3): 351-355, 2018 06.
Article en En | MEDLINE | ID: mdl-29746434
BACKGROUND: Therapeutic drug monitoring has become increasingly important in psychiatric therapy. However, it is not yet implemented as a daily routine in clinical settings. To evaluate new, noninvasive procedures, we compared blood and saliva venlafaxine, quetiapine, and citalopram concentrations in samples collected from psychiatric patients. METHODS: We collected blood and saliva samples from 75 psychiatric patients (39 venlafaxine, 19 quetiapine, and 17 citalopram). Saliva sampling was achieved by the use of cotton pads. Venlafaxine (and its metabolite O-desmethylvenlafaxine) and quetiapine were analyzed by LC-MS/MS, whereas citalopram was analyzed by HPLC. RESULTS: We observed significant correlations between concentrations of venlafaxine (ratio saliva/serum ± SD: 18.3 ± 9.5, P < 0.01, r = 0.895) and its metabolite O-desmethylvenlafaxine (ratio saliva/serum ± SD: 4.1 ± 3.2, P < 0.05, r = 0.344), quetiapine (ratio saliva/serum ± SD: 0.2 ± 0.2, P < 0.01, r = 0.935), and citalopram (ratio saliva/serum ± SD: 2.6 ± 1.2, P < 0.05, r = 0.54) in serum and in saliva. Furthermore, measured concentrations of venlafaxine (and its metabolite O-desmethylvenlafaxine) and citalopram were higher in saliva than in serum, whereas measured concentrations of quetiapine were higher in serum than in saliva. CONCLUSIONS: Using cotton pad saliva sampling, venlafaxine and quetiapine demonstrate high correlations between saliva and serum concentrations, whereas for O-desmethylvenlafaxine and citalopram, other methods of sampling might be preferable. Saliva therapeutic drug monitoring of psychoactive drugs might become a useful approach to achieving individual treatment regimens.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Citalopram / Succinato de Desvenlafaxina / Clorhidrato de Venlafaxina / Fumarato de Quetiapina / Trastornos Mentales Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ther Drug Monit Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Citalopram / Succinato de Desvenlafaxina / Clorhidrato de Venlafaxina / Fumarato de Quetiapina / Trastornos Mentales Tipo de estudio: Diagnostic_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Ther Drug Monit Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos