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Peripheral CD4+CD28null T-cells as predictors of damage in systemic lupus erythematosus patients.
Ugarte-Gil, Manuel F; Sánchez-Zúñiga, César; Gamboa-Cardenas, Rocio V; Aliaga-Zamudio, Madeley; Zevallos, Francisco; Mosqueira-Riveros, Ana; Medina-Chinchón, Mariela; Tineo-Pozo, Giannina; Elera-Fitzcarrald, Claudia; Pimentel-Quiroz, Victor; Sarmiento-Velasquez, Omar; Reátegui-Sokolova, Cristina; Cucho-Venegas, Jorge M; Alfaro-Lozano, José; Rodriguez-Bellido, Zoila; Pastor-Asurza, César; Alarcón, Graciela S; Perich-Campos, Risto.
Afiliación
  • Ugarte-Gil MF; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Científica del Sur, Lima, Perú. manuel_ugarte@yahoo.com.
  • Sánchez-Zúñiga C; Diagnostic Support Department, Hospital Grau, EsSalud, Lima, Perú.
  • Gamboa-Cardenas RV; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Aliaga-Zamudio M; Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Zevallos F; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Mosqueira-Riveros A; Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Medina-Chinchón M; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Tineo-Pozo G; Molecular Biology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Elera-Fitzcarrald C; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Científica del Sur, Lima, Perú.
  • Pimentel-Quiroz V; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Sarmiento-Velasquez O; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Reátegui-Sokolova C; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Cucho-Venegas JM; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Alfaro-Lozano J; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, Perú.
  • Rodriguez-Bellido Z; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.
  • Pastor-Asurza C; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.
  • Alarcón GS; School of Medicine, University of Alabama at Birmingham, AL, USA.
  • Perich-Campos R; Rheumatology Department, Hospital Guillermo Almenara Irigoyen, EsSalud, Lima, and Universidad Nacional Mayor de San Marcos, Lima, Perú.
Clin Exp Rheumatol ; 36(6): 1008-1013, 2018.
Article en En | MEDLINE | ID: mdl-29745892
OBJECTIVES: To determine whether the CD4+CD28null T-cells subpopulation predicts the occurrence of damage in SLE. METHODS: This longitudinal study was conducted in consecutive SLE patients seen every six months in our Rheumatology Department since 2012. Patients in whom CD4+CD28null T-cells had been measured and who had at least one subsequent visit were included in the study. Survival analyses (univariable and multivariable Cox-regression models) were performed to determine the risk of overall and domain damage (as per the SLICC Damage Index - SDI) as a function of the frequency of this T-cell subpopulation. The multivariable model was adjusted for pertinent confounders. All analyses were performed using SPSS 21.0. RESULTS: One hundred and nineteen patients were evaluated; their mean (SD) age was 43.5 (11.9) years, 113 (95.0%) were female. Disease duration was 7.8 (7.0) years, the SLEDAI 5.3 (4.1) and the SDI 1.0 (1.4). The percentage of CD4+CD28null T-cells was 17.4 (14.0). The mean follow-up was 2.1 (0.8) years, and the mean number of visits per patient 3.5 (1.1). Forty-six (38.7%) patients increase at least one SDI point. In the univariable and multivariable analyses, the percentage of CD4+CD28null predicted the occurrence of lung damage [HR: 1.042 (CI95%: 1.001-1.085); p=0.047 and HR: 1.099 (CI95%1.020-1.184); p=0.013, respectively] but neither the total SDI score nor all other SDI domain scores were predicted by the percentage of CD4+CD28null cells. CONCLUSIONS: In SLE patients, CD4+CD28null T-cells predict the occurrence of new lung damage, independently of other risk factors but not of overall damage or damage on other domains.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Antígenos CD28 / Pulmón / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Peru Idioma: En Revista: Clin Exp Rheumatol Año: 2018 Tipo del documento: Article Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Antígenos CD28 / Pulmón / Lupus Eritematoso Sistémico Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Peru Idioma: En Revista: Clin Exp Rheumatol Año: 2018 Tipo del documento: Article Pais de publicación: Italia