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15 years' survey of safety and efficacy of Serenoa repens extract in benign prostatic hyperplasia patients with risk of progression.
Vinarov, Andrey Zinovievich; Spivak, Leonid Grigorievich; Platonova, Darina Vladimirovna; Rapoport, Leonid Mikhailovich; Korolev, Dmitry Olegovich.
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  • Vinarov AZ; 1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Spivak LG; 1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Platonova DV; 1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Rapoport LM; 2 Clinic of Urology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Korolev DO; 1 I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Urologia ; 86(1): 17-22, 2019 Feb.
Article en En | MEDLINE | ID: mdl-29741118
AIM:: The aim of this study is to investigate the efficacy and safety of long-term therapy with Serenoa repens extract with regard to halting benign prostatic hyperplasia progression. MATERIAL AND METHODS:: An open non-comparative observational study of the continuous use of S. repens plant extract at a dosage of 320 mg once a day for 15 years was performed in 30 patients at risk for benign prostatic hyperplasia progression. Changes in IPSS (International Prostatic Symptoms Scale) and QoL (Quality of life) scores and changes in Qmax, voided volume, residual urine volume, and prostate volume were evaluated during the study. RESULTS:: The study showed an absence of progression based on both subjective (the sum of scores on the IPSS and QoL scales) and objective (prostate volume, urination rate, residual urine volume) criteria. Furthermore, the patients had no adverse events related to the study drug, including prostate cancer. CONCLUSIONS:: The 15 years' study results suggest that taking S. repens plant extract continuously at a daily dose of 320 mg is an effective and safe way to prevent the progression of benign prostatic hyperplasia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperplasia Prostática / Extractos Vegetales / Serenoa / Fitoterapia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans / Male / Middle aged Idioma: En Revista: Urologia Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hiperplasia Prostática / Extractos Vegetales / Serenoa / Fitoterapia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies Aspecto: Patient_preference Límite: Humans / Male / Middle aged Idioma: En Revista: Urologia Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos