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Clinical Significance of Macrophage Polarization in Antibody-Mediated Rejection of Renal Allograft.
Kim, J; Choi, S-E; Lim, B J; Kim, Y S; Huh, K H; Lee, J; Kim, S I; Kim, M S; Jeong, H J.
Afiliación
  • Kim J; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Choi SE; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Lim BJ; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
  • Kim YS; Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • Huh KH; Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • Lee J; Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • Kim SI; Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • Kim MS; Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea.
  • Jeong HJ; Department of Pathology, Yonsei University College of Medicine, Seoul, Korea. Electronic address: jeong10@yuhs.ac.
Transplant Proc ; 50(4): 1005-1008, 2018 May.
Article en En | MEDLINE | ID: mdl-29731056
BACKGROUND: The significance of proinflammatory M1 (classically activated) and profibrotic M2 (alternatively activated) macrophages in antibody-mediated rejection (ABMR) after kidney transplantation has not been investigated. METHODS: Fifty-five biopsy-confirmed ABMR samples were stained with MRP 8/14 (a marker of M1 macrophages) and CD163 (a marker of M2 macrophages), and positive cells were counted in glomeruli and the tubulointerstitium, respectively. Patients were classified into M1 and M2 polarization groups according to the glomerular and tubulointerstitial M1:M2 ratio, and the results were compared with Banff scores, serum creatinine level, estimated glomerular filtration rate (eGFR), and graft survival. RESULTS: The glomerular M2 polarization group showed significantly higher chronic glomerulopathy scores, serum creatinine levels, and lower eGFR at the time of biopsy (P = .019 and P = .015, respectively) and 3-month postbiopsy (P = .016 and P = .032, respectively) than the M1 polarization group. The tubulointerstitial M2 polarization group had significantly lower glomerulitis, arteritis, peritubular capillaritis, and glomerulitis + peritubular capillaritis scores than the M1 polarization group, but there was no significant difference in renal function. Long-term graft survival was not associated with macrophage polarization. CONCLUSION: Glomerular M2 polarization in ABMR biopsy samples is associated with chronic glomerular injury and poorer graft function, but without graft survival.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Rechazo de Injerto / Supervivencia de Injerto / Macrófagos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trasplante de Riñón / Rechazo de Injerto / Supervivencia de Injerto / Macrófagos Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos