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The protective effect of extra-virgin olive oil in the experimental model of multiple sclerosis in the rat.
Conde, C; Escribano, B M; Luque, E; Aguilar-Luque, M; Feijóo, M; Ochoa, J J; LaTorre, M; Giraldo, A I; Lillo, R; Agüera, E; Santamaría, A; Túnez, I.
Afiliación
  • Conde C; Neurology Service, Reina Sofia University Hospital, Cordoba, Spain.
  • Escribano BM; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
  • Luque E; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
  • Aguilar-Luque M; Department of Cell Biology, Physiology and Immunology, Faculty of Veterinary Medicine, University of Cordoba, Spain.
  • Feijóo M; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
  • Ochoa JJ; Department of Morphological Sciences, Histology Section, Faculty of Medicine and Nursing, University of Cordoba, Spain.
  • LaTorre M; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
  • Giraldo AI; Department of Biochemistry and Molecular Biology, Faculty of Medicine and Nursing, University of Cordoba, Spain.
  • Lillo R; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
  • Agüera E; Department of Biochemistry and Molecular Biology, Faculty of Medicine and Nursing, University of Cordoba, Spain.
  • Santamaría A; Neurology Service, Reina Sofia University Hospital, Cordoba, Spain.
  • Túnez I; Maimonides Institute for Research in Biomedicine of Cordoba, (IMIBC), Cordoba, Spain.
Nutr Neurosci ; 23(1): 37-48, 2020 Jan.
Article en En | MEDLINE | ID: mdl-29730972
This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE).Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated.Gastric administration of EVOO, OA, and HT reduced the degree of lipid and protein oxidation, and increased glutathione peroxidase, making it a diet-based mechanism for enhancing protection against oxidative damage. In addition, it reduced the levels of LPS and LBP, which appeared as being increased in the EAE correlated with the oxidative stress produced by the disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Encéfalo / Encefalomielitis Autoinmune Experimental / Aceite de Oliva / Esclerosis Múltiple Límite: Animals Idioma: En Revista: Nutr Neurosci Asunto de la revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Espinal / Encéfalo / Encefalomielitis Autoinmune Experimental / Aceite de Oliva / Esclerosis Múltiple Límite: Animals Idioma: En Revista: Nutr Neurosci Asunto de la revista: CIENCIAS DA NUTRICAO / NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido