The role of type I interferons (IFNs) in the regulation of chicken macrophage inflammatory response to bacterial challenge.
Dev Comp Immunol
; 86: 156-170, 2018 09.
Article
en En
| MEDLINE
| ID: mdl-29729283
Mammalian type I interferons (IFNα/ß) are known to modulate inflammatory processes in addition to their antiviral properties. Indeed, virus-induced type I interferons regulate the mammalian phagocyte immune response to bacteria during superinfections. However, it remains unresolved whether type I IFNs similarly impact the chicken macrophage immune response. We first evidenced that IFNα and IFNß act differently in terms of gene expression stimulation and activation of intracellular signaling pathways in chicken macrophages. Next, we showed that priming of chicken macrophages with IFNα increased bacteria uptake, boosted bacterial-induced ROS/NO production and led to an increased transcriptional expression or production of NOS2/NO, IL1B/IL-1ß and notably IFNB/IFNß. Neutralization of IFNß during bacterial challenge limited IFNα-induced augmentation of the pro-inflammatory response. In conclusion, we demonstrated that type I IFNs differently regulate chicken macrophage functions and drive a pro-inflammatory response to bacterial challenge. These findings shed light on the diverse functions of type I IFNs in chicken macrophages.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Bacterias
/
Pollos
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Interferón beta
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Interferón-alfa
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Inflamación
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Macrófagos
Límite:
Animals
Idioma:
En
Revista:
Dev Comp Immunol
Año:
2018
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Estados Unidos