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African-American race and mortality in interstitial lung disease: a multicentre propensity-matched analysis.
Adegunsoye, Ayodeji; Oldham, Justin M; Bellam, Shashi K; Chung, Jonathan H; Chung, Paul A; Biblowitz, Kathleen M; Montner, Steven; Lee, Cathryn; Hsu, Scully; Husain, Aliya N; Vij, Rekha; Mutlu, Gokhan; Noth, Imre; Churpek, Matthew M; Strek, Mary E.
Afiliación
  • Adegunsoye A; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Oldham JM; Division of Pulmonary, Critical Care and Sleep Medicine, Dept of Medicine, University of California at Davis, Davis, CA, USA.
  • Bellam SK; Division of Pulmonary and Critical Care, Dept of Medicine, NorthShore University HealthSystem, Evanston, IL, USA.
  • Chung JH; Dept of Radiology, The University of Chicago, Chicago, IL, USA.
  • Chung PA; Dept of Medicine, NorthShore University HealthSystem, Evanston, IL, USA.
  • Biblowitz KM; Dept of Medicine, NorthShore University HealthSystem, Evanston, IL, USA.
  • Montner S; Dept of Radiology, The University of Chicago, Chicago, IL, USA.
  • Lee C; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Hsu S; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Husain AN; Dept of Pathology, The University of Chicago, Chicago, IL, USA.
  • Vij R; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Mutlu G; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Noth I; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Churpek MM; Section of Pulmonary and Critical Care, Dept of Medicine, The University of Chicago, Chicago, IL, USA.
  • Strek ME; Dept of Public Health Sciences, The University of Chicago, Chicago, IL, USA.
Eur Respir J ; 51(6)2018 06.
Article en En | MEDLINE | ID: mdl-29724923
We studied whether African-American race is associated with younger age and decreased survival time at diagnosis of interstitial lung disease (ILD).We performed a multicentre, propensity score-matched analysis of patients with an ILD diagnosis followed at five US hospitals between 2006 and 2016. African-Americans were matched with patients of other races based on a time-dependent propensity score calculated from multiple patient, physiological, diagnostic and hospital characteristics. Multivariable logistic regression models were used. All-cause mortality and hospitalisations were compared between race-stratified patient cohorts with ILD, and sensitivity analyses were performed.The study included 1640 patients with ILD, 13% of whom were African-American, followed over 5041 person-years. When compared with patients of other races, African-Americans with ILD were younger at diagnosis (56 years versus 67 years), but in the propensity-matched analyses had greater survival (hazard ratio 0.46, 95% CI 0.28-0.77; p=0.003) despite similar risk of respiratory hospitalisations (relative risk 1.04, 95% CI 0.83-1.31; p=0.709), and similar GAP-ILD (gender-age-physiology-ILD) scores at study entry. Sensitivity analyses in a separate cohort of 9503 patients with code-based ILD diagnosis demonstrated a similar association of baseline demographic characteristics with all-cause mortality.We conclude that African-Americans demonstrate a unique phenotype associated with younger age at ILD diagnosis and perhaps longer survival time.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Enfermedades Pulmonares Intersticiales / Hospitalización Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Eur Respir J Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Negro o Afroamericano / Enfermedades Pulmonares Intersticiales / Hospitalización Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Determinantes_sociais_saude Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Eur Respir J Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido