Abolishment of the positive feedback mechanism: a criterion for temporary medical hypophysectomy by LH-RH agonist.
Gynecol Endocrinol
; 1(1): 1-11, 1987 Mar.
Article
en En
| MEDLINE
| ID: mdl-2972166
The hypothalamic pituitary axis was studied in patients with an abnormal pattern of gonadotropin release during chronic treatment with LH-RH agonist. Two patients had PCOD and the third demonstrated the early luteinization phenomenon. Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Stabilization of the LH:FSH ratio in PCOD patients was noted after 4 weeks of treatment. Administration of both native LH-RH (100 micrograms) and intravenous pulsatile LH-RH did not evoke any rise in LH. In addition to the above LH-RH challenges, the positive feedback was examined by administration of estradiol benzoate (EB). The study demonstrated that, although the pituitary did not respond to any LH-RH challenge, it may still respond by a rise in LH following EB administration. Both functions of the hypothalamic pituitary axis should be examined in order to determine the state of medical hypophysectomy.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome del Ovario Poliquístico
/
Hormona Liberadora de Gonadotropina
/
Buserelina
/
Hipofisectomía
/
Hipofisectomía Química
/
Infertilidad Femenina
/
Luteolíticos
Límite:
Female
/
Humans
Idioma:
En
Revista:
Gynecol Endocrinol
Asunto de la revista:
ENDOCRINOLOGIA
/
GINECOLOGIA
Año:
1987
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Reino Unido