Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased <i>in vivo</i> anti-tumor efficacy.

Feng, Junnan; Zhao, Chuanke; Wang, Lixin; Qu, Like; Zhu, Hua; Yang, Zhi; An, Guo; Tian, Huifang; Shou, Chengchao

Development of a novel albumin-based and maleimidopropionic acid-conjugated peptide with prolonged half-life and increased in vivo anti-tumor efficacy.

Feng, Junnan; Zhao, Chuanke; Wang, Lixin; Qu, Like; Zhu, Hua; Yang, Zhi; An, Guo; Tian, Huifang; Shou, Chengchao.

Afiliación

Feng J; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zhao C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Wang L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Qu L; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Zhu H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Yang Z; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China.
An G; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Laboratory Animal, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Tian H; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Central Laboratory, Peking University Cancer Hospital & Institute, Beijing 100142, China.
Shou C; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Theranostics ; 8(8): 2094-2106, 2018.

Article en En | MEDLINE | ID: mdl-29721065

Asunto(s)

Albúminas/química; Antineoplásicos/farmacología; Maleimidas/farmacología; Oligopéptidos/farmacología; Propionatos/farmacología; Animales; Antineoplásicos/química; Línea Celular; Movimiento Celular/efectos de los fármacos; Embrión no Mamífero/metabolismo; Semivida; Humanos; Masculino; Maleimidas/química; Ratones Endogámicos BALB C; Metástasis de la Neoplasia; Neovascularización Fisiológica/efectos de los fármacos; Oligopéptidos/química; Oligopéptidos/farmacocinética; Fosfatidilinositol 3-Quinasas/metabolismo; Fosforilación/efectos de los fármacos; Propionatos/química; Proteínas Proto-Oncogénicas c-akt/metabolismo; Receptor 1 de Factores de Crecimiento Endotelial Vascular/metabolismo; Ensayos Antitumor por Modelo de Xenoinjerto; Pez Cebra/embriología

Palabras clave

F56; MPA; VEGFR1; albumin conjugate; anti-tumor

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oligopéptidos / Propionatos / Albúminas / Maleimidas / Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Theranostics Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia

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