Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment.

Andonegui, Graciela; Zelinski, Erin L; Schubert, Courtney L; Knight, Derrice; Craig, Laura A; Winston, Brent W; Spanswick, Simon C; Petri, Björn; Jenne, Craig N; Sutherland, Janice C; Nguyen, Rita; Jayawardena, Natalie; Kelly, Margaret M; Doig, Christopher J; Sutherland, Robert J; Kubes, Paul

Andonegui, Graciela; Zelinski, Erin L; Schubert, Courtney L; Knight, Derrice; Craig, Laura A; Winston, Brent W; Spanswick, Simon C; Petri, Björn; Jenne, Craig N; Sutherland, Janice C; Nguyen, Rita; Jayawardena, Natalie; Kelly, Margaret M; Doig, Christopher J; Sutherland, Robert J; Kubes, Paul.

Afiliación

Andonegui G; Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and.
Zelinski EL; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Schubert CL; Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Alberta, Canada.
Knight D; Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and.
Craig LA; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Winston BW; Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and.
Spanswick SC; Regeneration Unit in Neurobiology Facility, Hotchkiss Brain Institute.
Petri B; Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and.
Jenne CN; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Sutherland JC; Department of Medicine.
Nguyen R; Department of Biochemistry and Molecular Biology.
Jayawardena N; Regeneration Unit in Neurobiology Facility, Hotchkiss Brain Institute.
Kelly MM; Department of Microbiology, Immunology and Infectious Diseases.
Doig CJ; Mouse Phenomics Resource Laboratory, Snyder Institute for Chronic Diseases.
Sutherland RJ; Immunology Research Group, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, and.
Kubes P; Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

JCI Insight ; 3(9)2018 05 03.

Article en En | MEDLINE | ID: mdl-29720578

Asunto(s)

Encéfalo/patología; Disfunción Cognitiva/patología; Citocinas/sangre; Inflamación/sangre; Monocitos/patología; Encefalopatía Asociada a la Sepsis/patología; Adulto; Anciano; Animales; Anticuerpos Monoclonales/uso terapéutico; Disfunción Cognitiva/microbiología; Modelos Animales de Enfermedad; Femenino; Humanos; Inflamación/microbiología; Interleucina-8/antagonistas & inhibidores; Interleucina-8/inmunología; Microscopía Intravital; Masculino; Pruebas de Estado Mental y Demencia; Ratones; Microglía/fisiología; Persona de Mediana Edad; Monocitos/metabolismo; Neutrófilos/patología; Infecciones Neumocócicas/complicaciones; Receptores CCR2/antagonistas & inhibidores; Receptores CCR2/inmunología; Receptores CCR2/metabolismo; Encefalopatía Asociada a la Sepsis/sangre; Encefalopatía Asociada a la Sepsis/microbiología

Palabras clave

Bacterial infections; Inflammation; Innate immunity; Neuroscience

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Monocitos / Citocinas / Disfunción Cognitiva / Encefalopatía Asociada a la Sepsis / Inflamación Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: JCI Insight Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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