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Influence of Body Mass Index on Clinical Outcome Parameters, Complication Rate and Survival after Radical Cystectomy: Evidence from a Prospective European Multicentre Study.
Gierth, Michael; Zeman, Florian; Denzinger, Stefan; Vetterlein, Malte W; Fisch, Margit; Bastian, Patrick J; Syring, Isabella; Ellinger, Jörg; Müller, Stephan C; Herrmann, Edwin; Gilfrich, Christian; May, Matthias; Pycha, Armin; Wagenlehner, Florian M; Vallo, Stefan; Bartsch, Georg; Haferkamp, Axel; Grimm, Marc-Oliver; Roigas, Jan; Protzel, Chris; Hakenberg, Oliver W; Fritsche, Hans-Martin; Burger, Maximilian; Aziz, Atiqullah; Mayr, Roman.
Afiliación
  • Gierth M; Department of Urology, University of Regensburg, Regensburg, Germany.
  • Zeman F; Center for Statistics and Clinical Studies, University of Regensburg, Regensburg, Germany.
  • Denzinger S; Department of Urology, University of Regensburg, Regensburg, Germany.
  • Vetterlein MW; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Fisch M; Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Bastian PJ; Department of Urology, Marienhospital Düsseldorf, Düsseldorf, Germany.
  • Syring I; Department of Urology, University Medical Center Bonn, Bonn, Germany.
  • Ellinger J; Department of Urology, University Medical Center Bonn, Bonn, Germany.
  • Müller SC; Department of Urology, University Medical Center Bonn, Bonn, Germany.
  • Herrmann E; Department of Urology, University Medical Center Münster, Münster, Germany.
  • Gilfrich C; Department of Urology, St. Elisabeth Medical Center, Straubing, Germany.
  • May M; Department of Urology, St. Elisabeth Medical Center, Straubing, Germany.
  • Pycha A; Department of Urology, Central Hospital Bolzano, Bolzano, Italy.
  • Wagenlehner FM; Department of Urology, Pediatric Urology and Andrology, Justus Liebig University of Giessen, Giessen, Germany.
  • Vallo S; Department of Urology, Goethe University Frankfurt, Frankfurt, Germany.
  • Bartsch G; Department of Urology, University Medical Center Mainz, Mainz, Germany.
  • Haferkamp A; Department of Urology, University Medical Center Mainz, Mainz, Germany.
  • Grimm MO; Department of Urology, Jena University Hospital, Jena, Germany.
  • Roigas J; Department of Urology, Vivantes Medical Centre Im Friedrichshain and Am Urban, Berlin, Germany.
  • Protzel C; Department of Urology, University Medical Center Rostock, Rostock, Germany.
  • Hakenberg OW; Department of Urology, University Medical Center Rostock, Rostock, Germany.
  • Fritsche HM; Department of Urology, University of Regensburg, Regensburg, Germany.
  • Burger M; Department of Urology, University of Regensburg, Regensburg, Germany.
  • Aziz A; Department of Urology, University Medical Center Rostock, Rostock, Germany.
  • Mayr R; Department of Urology, University of Regensburg, Regensburg, Germany.
Urol Int ; 101(1): 16-24, 2018.
Article en En | MEDLINE | ID: mdl-29719296
Background/Aims/Objectives: To evaluate the influence of body mass index (BMI) on complications and oncological outcomes in patients undergoing radical cystectomy (RC). METHODS: Clinical and histopathological parameters of patients have been prospectively collected within the "PROspective MulticEnTer RadIcal Cystectomy Series 2011". BMI was categorized as normal weight (<25 kg/m2), overweight (≥25-29.9 kg/m2) and obesity (≥30 kg/m2). The association between BMI and clinical and histopathological endpoints was examined. Ordinal logistic regression models were applied to assess the influence of BMI on complication rate and survival. RESULTS: Data of 671 patients were eligible for final analysis. Of these patients, 26% (n = 175) showed obesity. No significant association of obesity on tumour stage, grade, lymph node metastasis, blood loss, type of urinary diversion and 90-day mortality rate was found. According to the -American Society of Anesthesiologists score, local lymph node (NT) stage and operative case load patients with higher BMI had significantly higher probabilities of severe complications 30 days after RC (p = 0.037). The overall survival rate of obese patients was superior to normal weight patients (p = 0.019). CONCLUSIONS: There is no evidence of correlation between obesity and worse oncological outcomes after RC. While obesity should not be a parameter to exclude patients from cystectomy, surgical settings need to be aware of higher short-term complication risks and obese patients should be counselled -accordingly.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Índice de Masa Corporal / Cistectomía Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Urol Int Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria / Índice de Masa Corporal / Cistectomía Tipo de estudio: Clinical_trials / Diagnostic_studies / Observational_studies / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Urol Int Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza