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Immunomodulatory activity and chemical characterization of fixed oils obtained from different parts of Oxytropis glabra DC.
Mehtab, Rabia; Ibrahim, Muhammad; Naz, Asia; Faiyaz, Ambreen; Faheem, Aisha; Rasheed, Munawwer; Saify, Zafar Saeed.
Afiliación
  • Mehtab R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
  • Ibrahim M; Department of Chemistry, Faculty of Science, University of Karachi, Karachi, Pakistan / Pakistan Standards and Quality Control Authority, Pakistan Secretariat, Karachi, Pakistan.
  • Naz A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
  • Faiyaz A; Department of Biochemistry, King Saud bin Abdul Aziz University, Jeddah, Saudi Arabia.
  • Faheem A; Dr. Panjwani Centre for Molecular Medicine and Drug Research Centre, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
  • Rasheed M; Centre of Excellence in Marine Biology, University of Karachi, Karachi, Pakistan.
  • Saify ZS; HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan.
Pak J Pharm Sci ; 31(3): 755-762, 2018 May.
Article en En | MEDLINE | ID: mdl-29716852
Oxytropis glabra DC. is a plant with enormous therapeutic vitality. In the present study a comparison of lipophilic profiling of different parts of O. glabra has been carried out by using gas chromatography-mass spectrometry. A total of 32 compounds have been identified from this plant, amongst which 31 have been identified for the first time. These compounds have been further confirmed from their Van den Dool and Kratz (I) Indices. Out of these 32 compounds, 18 have been identified from flower (80.94%), 15 from fruit (85.36%), 11 from leaves (66.35%) and 11 from root (45.96%). The major class of metabolite identified from different parts is fatty acid. Hydrocarbons have also been detected in flower and fruit but not in root and leaves. The extracts were screened for their immunomodulatory activity on whole blood cells. The root oil was found to be moderately active (IC50 32.3 µg/mL). At present only limited data is available on the phytochemical composition of O. glabra.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Plantas / Extractos Vegetales / Raíces de Plantas / Oxytropis / Componentes Aéreos de las Plantas / Factores Inmunológicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aceites de Plantas / Extractos Vegetales / Raíces de Plantas / Oxytropis / Componentes Aéreos de las Plantas / Factores Inmunológicos Tipo de estudio: Prognostic_studies Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán