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Accuracy of the 2008 Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Children.
Arcos-Machancoses, José Vicente; Molera Busoms, Cristina; Julio Tatis, Ecaterina; Victoria Bovo, María; Quintero Bernabeu, Jesús; Juampérez Goñi, Javier; Crujeiras Martínez, Vanessa; Martin de Carpi, Javier.
Afiliación
  • Arcos-Machancoses JV; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Déu Hospital (SJDH), Barcelona, Spain.
  • Molera Busoms C; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Déu Hospital (SJDH), Barcelona, Spain.
  • Julio Tatis E; SJDH-VHH Comprehensive Unit of Complex Hepatology and Pediatric Liver Transplantation, Barcelona, Spain.
  • Victoria Bovo M; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Déu Hospital (SJDH), Barcelona, Spain.
  • Quintero Bernabeu J; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Déu Hospital (SJDH), Barcelona, Spain.
  • Juampérez Goñi J; Department of Pediatric Gastroenterology and Hepatology, Vall d'Hebron Hospital (VHH), Barcelona, Spain.
  • Crujeiras Martínez V; SJDH-VHH Comprehensive Unit of Complex Hepatology and Pediatric Liver Transplantation, Barcelona, Spain.
  • Martin de Carpi J; Department of Pediatric Gastroenterology and Hepatology, Vall d'Hebron Hospital (VHH), Barcelona, Spain.
Pediatr Gastroenterol Hepatol Nutr ; 21(2): 118-126, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29713609
PURPOSE: Classical criteria for diagnosis of autoimmune hepatitis (AIH) are intended as research tool and are difficult to apply at patient's bedside. We aimed to study the accuracy of simplified criteria and the concordance with the expert diagnosis based on the original criteria. METHODS: A cohort of children under study for liver disorder was selected through consecutive sampling to obtain the prevalence of AIH within the group of differential diagnoses. AIH was defined, based on classical criteria, through committee review of medical reports. Validity indicators of the simplified criteria were obtained in an intention to diagnose approach. Optimal cut-off and the area under the receiver operating characteristic (ROC) curve were calculated. RESULTS: Out of 212 cases reviewed, 47.2% were AIH. For the optimal cut-off (6 points), the simplified criteria showed a sensitivity of 72.0% and a specificity of 96.4%, with a 94.7% positive and a 79.4% negative predictive value. The area under the ROC curve was 94.3%. There was a good agreement in the pre-treatment concordance between the classical and the simplified criteria (kappa index, 0.775). CONCLUSION: Simplified criteria provide a moderate sensitivity for the diagnosis of AIH, but may help in indicating treatment in cases under suspicion with 6 or more points.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Pediatr Gastroenterol Hepatol Nutr Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Corea del Sur