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Characterizing the Effects of Quetiapine in Military Post-Traumatic Stress Disorder.
Villarreal, Gerardo; Hamner, Mark B; Qualls, Clifford; Cañive, José M.
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  • Villarreal G; Dr. Villarreal, Behavioral Health Care Line (BHCL), Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico, and Departments of Psychiatry and Neurosciences, University of New Mexico School of Medicine, New Mexico. Dr. Hamner, MD, Department of Psychiatry and Behavioral Sciences, Medical Univer
  • Hamner MB; Dr. Villarreal, Behavioral Health Care Line (BHCL), Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico, and Departments of Psychiatry and Neurosciences, University of New Mexico School of Medicine, New Mexico. Dr. Hamner, MD, Department of Psychiatry and Behavioral Sciences, Medical Univer
  • Qualls C; Dr. Villarreal, Behavioral Health Care Line (BHCL), Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico, and Departments of Psychiatry and Neurosciences, University of New Mexico School of Medicine, New Mexico. Dr. Hamner, MD, Department of Psychiatry and Behavioral Sciences, Medical Univer
  • Cañive JM; Dr. Villarreal, Behavioral Health Care Line (BHCL), Raymond G. Murphy VA Medical Center, Albuquerque, New Mexico, and Departments of Psychiatry and Neurosciences, University of New Mexico School of Medicine, New Mexico. Dr. Hamner, MD, Department of Psychiatry and Behavioral Sciences, Medical Univer
Psychopharmacol Bull ; 48(2): 8-17, 2018 02 05.
Article en En | MEDLINE | ID: mdl-29713096
Objectives: A previous randomized placebo-controlled trial in military veterans posttraumatic stress disorder (PTSD) found that quetiapine improved global PTSD symptoms severity, depression and anxiety as well as the re-experiencing and hypearousal clusters. However, it is not known if individual symptoms had a preferential response to this medication. The goal of this study was to analyze the individual symptom response in this group of patients. Methods: Data from a previous trial was re-analyzed. Each of the of the scale items was analyzed individually using Repeated Measures Analysis of Variance. Results: Compared to placebo, there was a significant decline in the Clinician-Administered PTSD Scale intrusive memories and insomnia questions. In the Davidson Trauma Scale, greater improvements were observed on irritability, difficulty concentrating, hyperstartle and a trend was observed on avoiding thoughts or feelings about the event. Greater improvements compared with placebo were noted on the Hamilton Depression (HAM-D) middle and late insomnia items. On the Hamilton Anxiety scale (HAM-A), the insomnia item was significantly improved. Conclusions: Quetiapine demonstrated greater effect than placebo on several symptoms. The strongest response was seen on insomnia, which the highest significance level on the CAPS. The insomnia items of both the HAM-D and HAM-A also demonstrated improvement with quetiapine. These finding indicate quetiapine improved sleep measure. Insomnia can be a difficult problem to treat in PTSD patients, therefore quetiapine should be considered in difficult cases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Antipsicóticos / Evaluación de Resultado en la Atención de Salud / Trastornos de Combate / Fumarato de Quetiapina Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: Psychopharmacol Bull Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Antipsicóticos / Evaluación de Resultado en la Atención de Salud / Trastornos de Combate / Fumarato de Quetiapina Tipo de estudio: Clinical_trials Límite: Adult / Humans / Male Idioma: En Revista: Psychopharmacol Bull Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos