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Prenatal lead exposure in relation to age at menarche: results from a longitudinal study in Mexico City.
Jansen, E C; Zhou, L; Song, P X K; Sánchez, B N; Mercado, A; Hu, H; Solano, M; Peterson, K E; Tellez-Rojo, M M.
Afiliación
  • Jansen EC; 1Department of Nutritional Sciences,University of Michigan,Ann Arbor,MI,USA.
  • Zhou L; 2Department of Biostatistics,University of Michigan,Ann Arbor,MI,USA.
  • Song PXK; 2Department of Biostatistics,University of Michigan,Ann Arbor,MI,USA.
  • Sánchez BN; 2Department of Biostatistics,University of Michigan,Ann Arbor,MI,USA.
  • Mercado A; 3Center for Nutrition and Health Research,National Institute of Public Health,Cuernavaca,Morelos,Mexico.
  • Hu H; 4Occupational and Environmental Health,Dalla Lana School of Public Health,University of Toronto,Toronto,ON,Canada.
  • Solano M; 3Center for Nutrition and Health Research,National Institute of Public Health,Cuernavaca,Morelos,Mexico.
  • Peterson KE; 1Department of Nutritional Sciences,University of Michigan,Ann Arbor,MI,USA.
  • Tellez-Rojo MM; 1Department of Nutritional Sciences,University of Michigan,Ann Arbor,MI,USA.
J Dev Orig Health Dis ; 9(4): 467-472, 2018 08.
Article en En | MEDLINE | ID: mdl-29706142
Animal and cross-sectional epidemiological studies suggest that prenatal lead exposure is related to delayed menarche, but this has not been confirmed in longitudinal studies. We analyzed this association among 200 girls from Mexico City who were followed since the first trimester of gestation. Maternal blood lead levels were analyzed once during each trimester of pregnancy, and daughters were asked about their first menstrual cycle at a visit between the ages of 9.8 and 18.1 years. We estimated hazard ratios (HRs) and 95% confidence intervals (CI) for probability of menarche over the follow-up period using interval-censored Cox models, comparing those with prenatal blood lead level ⩾5 µg/dl to those with prenatal blood lead <5 µg/dl. We also estimated HRs and 95% CI with conventional Cox regression models, which utilized the self-reported age at menarche. In adjusted analyses, we accounted for maternal age, maternal parity, maternal education, and prenatal calcium treatment status. Across trimesters, 36-47% of mothers had blood lead levels ⩾5 µg/dl. Using interval-censored models, we found that during the second trimester only, girls with ⩾5 µg/dl prenatal blood lead had a later age at menarche compared with girls with prenatal blood lead levels <5 µg/dl (confounder-adjusted HR=0.59, 95% CI 0.28-0.90; P=0.05). Associations were in a similar direction, although not statistically significant, in the conventional Cox regression models, potentially indicating measurement error in the self-recalled age at menarche. In summary, higher prenatal lead exposure during the second trimester could be related to later onset of sexual maturation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Maduración Sexual / Menarquia / Exposición Materna / Plomo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: J Dev Orig Health Dis Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efectos Tardíos de la Exposición Prenatal / Maduración Sexual / Menarquia / Exposición Materna / Plomo Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Pregnancy País/Región como asunto: Mexico Idioma: En Revista: J Dev Orig Health Dis Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido