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Mouse Testing Methods in Psychoneuroimmunology 2.0: Measuring Behavioral Responses.
Towers, Albert E; York, Jason M; Baynard, Tracy; Gainey, Stephen J; Freund, Gregory G.
Afiliación
  • Towers AE; Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA.
  • York JM; School of Molecular and Cellular Biology, University of Illinois, Chicago, IL, USA.
  • Baynard T; Department of Kinesiology and Nutrition, University of Illinois, Chicago, IL, USA.
  • Gainey SJ; Department of Animal Sciences, University of Illinois, Urbana, IL, USA.
  • Freund GG; Division of Nutritional Sciences, University of Illinois, Urbana, IL, USA. freun@illinois.edu.
Methods Mol Biol ; 1781: 221-258, 2018.
Article en En | MEDLINE | ID: mdl-29705851
The field of psychoneuroimmunology (PNI) aims to uncover the processes and consequences of nervous, immune, and endocrine system relationships. Behavior is a consequence of such interactions and manifests from a complex interweave of factors including immune-to-neural and neural-to-immune communication. Often the signaling molecules involved during a particular episode of neuroimmune activation are not known but behavioral response provides evidence that bioactives such as neurotransmitters and cytokines are perturbed. Immunobehavioral phenotyping is a first-line approach when examining the neuroimmune system and its reaction to immune stimulation or suppression. Behavioral response is significantly more sensitive than direct measurement of a single specific bioactive and can quickly and efficiently rule in or out relevance of a particular immune challenge or therapeutic to neuroimmunity. Classically, immunobehavioral research was focused on sickness symptoms related to bacterial infection but neuroimmune activation is now a recognized complication of diseases and disorders ranging from cancer to diabesity to Alzheimer's. Immunobehaviors include lethargy, loss of appetite, and disinterest in social activity/surrounding environment. In addition, neuroimmune activation can diminish physical activity, precipitate feelings of depression and anxiety, and impair cognitive and executive function. Provided is a detailed overview of behavioral tests frequently used to examine neuroimmune activation in mice with a special emphasis on pre-experimental conditions that can confound or prevent successful immunobehavioral experimentation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Encéfalo / Psiconeuroinmunología / Neuroinmunomodulación Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Encéfalo / Psiconeuroinmunología / Neuroinmunomodulación Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos