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Histologic and Clinical Changes in Vulvovaginal Tissue After Treatment With a Transcutaneous Temperature-Controlled Radiofrequency Device.
Vanaman Wilson, Monique J; Bolton, Joanna; Jones, Isabela T; Wu, Douglas C; Calame, Antoanella; Goldman, Mitchel P.
Afiliación
  • Vanaman Wilson MJ; California Skin Institute, Sunnyvale, California.
  • Bolton J; Alliant Dermatology, The Villages, Florida.
  • Jones IT; McLean Dermatology and Skincare Center, McLean, Virginia.
  • Wu DC; Goldman, Butterwick, Groff, Fabi and Wu, Cosmetic Laser Dermatology, San Diego, California.
  • Calame A; Compass Dermatopathology, San Diego, California.
  • Goldman MP; Department of Dermatology, University of California, San Diego, San Diego, California.
Dermatol Surg ; 44(5): 705-713, 2018 May.
Article en En | MEDLINE | ID: mdl-29701623
BACKGROUND: Although transcutaneous temperature-controlled radiofrequency (TTCRF) may effectively treat vulvovaginal laxity (VVL), atrophic vaginitis (AV), orgasmic dysfunction (OD), and stress urinary incontinence (SUI), there is a lack of histopathologic evidence to validate its use. OBJECTIVE: Evaluate clinical and histological changes induced by vulvovaginal TTCRF. MATERIALS AND METHODS: This was a prospective, nonrandomized trial. Ten female subjects with mild-to-moderate VVL, with or without AV, OD, and/or SUI underwent 3 TTCRFs at 4-week intervals. Five subjects underwent pre- and post-treatment biopsies of the labia majora and vaginal canal for histology. Assessments were performed at baseline and Days 10, 30, 60, and 120. RESULTS: Investigator-rated VVL improved significantly from baseline to Day 10, with improvement maintained through Day 120 (p = .001 and .001, respectively). Sexual satisfaction improved significantly by Day 60 (p = .001). Improvement in AV reached significance at Day 120 (p = .048). Although OD and SUI improved steadily, the difference in improvement did not reach statistical significance. Histology revealed that post-treatment increases in collagen, elastin, vascularity, and small nerve fibers. CONCLUSION: Transcutaneous temperature-controlled RF resulted in significant improvements in AV, VVL, and sexual satisfaction with milder improvements in OD and SUI. Post-treatment histology demonstrated neocollagenesis, neoelastogenesis, neoangiogenesis, and the first reported finding of TTCRF-related neurogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ondas de Radio / Vagina / Vulva / Satisfacción del Paciente Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Dermatol Surg Asunto de la revista: DERMATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ondas de Radio / Vagina / Vulva / Satisfacción del Paciente Tipo de estudio: Observational_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Dermatol Surg Asunto de la revista: DERMATOLOGIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos