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Lifetime-Encoded Infrared-Emitting Nanoparticles for in Vivo Multiplexed Imaging.
Ortgies, Dirk H; Tan, Meiling; Ximendes, Erving C; Del Rosal, Blanca; Hu, Jie; Xu, Lei; Wang, Xindong; Martín Rodríguez, Emma; Jacinto, Carlos; Fernandez, Nuria; Chen, Guanying; Jaque, Daniel.
Afiliación
  • Ortgies DH; Fluorescence Imaging Group, Departamento de Física de Materiales , Universidad Autónoma de Madrid , Madrid 28049 , Spain.
  • Tan M; Nanobiology Group , Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS , Ctra. Colmenar km. 9.100 , Madrid 28034 , Spain.
  • Ximendes EC; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-systems and Micro-structures, Ministry of Education , Harbin Institute of Technology , 150001 Harbin , People's Republic of China.
  • Del Rosal B; Grupo de Fotônica e Fluidos Complexos, Instituto de Física , Universidade Federal de Alagoas , 57072-900 Maceió-AL , Brazil.
  • Hu J; Centre for Micro-Photonics, Faculty of Science, Engineering and Technology , Swinburne University of Technology , P.O. Box 218, Hawthorn , VIC 3122 , Australia.
  • Xu L; Fluorescence Imaging Group, Departamento de Física de Materiales , Universidad Autónoma de Madrid , Madrid 28049 , Spain.
  • Wang X; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-systems and Micro-structures, Ministry of Education , Harbin Institute of Technology , 150001 Harbin , People's Republic of China.
  • Martín Rodríguez E; MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering & Key Laboratory of Micro-systems and Micro-structures, Ministry of Education , Harbin Institute of Technology , 150001 Harbin , People's Republic of China.
  • Jacinto C; Fluorescence Imaging Group, Departamento de Física Aplicada , Universidad Autónoma de Madrid , 28049 Madrid , Spain.
  • Fernandez N; Nanobiology Group , Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS , Ctra. Colmenar km. 9.100 , Madrid 28034 , Spain.
  • Chen G; Grupo de Fotônica e Fluidos Complexos, Instituto de Física , Universidade Federal de Alagoas , 57072-900 Maceió-AL , Brazil.
  • Jaque D; Fluorescence Imaging Group, Departamento de Fisiología, Facultad de Medicina, Avda. Arzobispo Morcillo 2 , Universidad Autónoma de Madrid , 28029 Madrid , Spain.
ACS Nano ; 12(5): 4362-4368, 2018 05 22.
Article en En | MEDLINE | ID: mdl-29697971
Advanced diagnostic procedures are required to satisfy the continuously increasing demands of modern biomedicine while also addressing the need for cost reduction in public health systems. The development of infrared luminescence-based techniques for in vivo imaging as reliable alternatives to traditional imaging enables applications with simpler and more cost-effective apparatus. To further improve the information provided by in vivo luminescence images, the design and fabrication of enhanced infrared-luminescent contrast agents is required. In this work, we demonstrate how simple dopant engineering can lead to infrared-emitting rare-earth-doped nanoparticles with tunable (0.1-1.5 ms) and medium-independent luminescence lifetimes. The combination of these tunable nanostructures with time-gated infrared imaging and time domain analysis is employed to obtain multiplexed in vivo images that are used for complex biodistribution studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Imagen Óptica / Metales de Tierras Raras Límite: Animals Idioma: En Revista: ACS Nano Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas / Imagen Óptica / Metales de Tierras Raras Límite: Animals Idioma: En Revista: ACS Nano Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos