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In vivo assessment of cyto/genotoxic, antigenotoxic and antifungal potential of Costus spiralis (Jacq.) Roscoe leaves and stems.
Sousa, Wendel C DE; T S Paz, Andressa; Rocha, Jamira D; Conceição, Edemilson C DA; Almeida, Luciane M DE; Chen, Lee C; Borges, Leonardo L; Bailão, Elisa F L C.
Afiliación
  • Sousa WC; Universidade Estadual de Goiás, Câmpus Iporá, Av. R2, Qd.01, Jardim Novo Horizonte II, 76200-000 Iporá, GO, Brazil.
  • T S Paz A; Laboratório de Pesquisa, Desenvolvimento & Inovação de Bioprodutos, Faculdade de Farmácia, Universidade Federal de Goiás, Rua 240, Setor Leste Universitário, 74605-170 Goiânia, GO, Brazil.
  • Rocha JD; Universidade Estadual de Goiás, Câmpus Iporá, Av. R2, Qd.01, Jardim Novo Horizonte II, 76200-000 Iporá, GO, Brazil.
  • Conceição ECD; Laboratório de Pesquisa, Desenvolvimento & Inovação de Bioprodutos, Faculdade de Farmácia, Universidade Federal de Goiás, Rua 240, Setor Leste Universitário, 74605-170 Goiânia, GO, Brazil.
  • Almeida LM; Laboratório de Biotecnologia, Universidade Estadual de Goiás, Câmpus Henrique Santillo, BR 153, nº 3.105, Fazenda Barreiro do Meio, 75132-903 Anápolis, GO, Brazil.
  • Chen LC; Departamento de Biologia Geral, Instituto de Ciências Biológicas I, Universidade Federal de Goiás, Câmpus Samambaia, Av. Esperança, s/n, 74690-900 Goiânia, GO, Brazil.
  • Borges LL; Laboratório de Biotecnologia, Universidade Estadual de Goiás, Câmpus Henrique Santillo, BR 153, nº 3.105, Fazenda Barreiro do Meio, 75132-903 Anápolis, GO, Brazil.
  • Bailão EFLC; Escola de Ciências Médicas, Farmacêuticas e Biomédicas, Pontifícia Universidade Católica de Goiás, Av. Universitária, 1440, Setor Universitário, 74605-010 Goiânia, GO, Brazil.
An Acad Bras Cienc ; 90(2): 1565-1577, 2018.
Article en En | MEDLINE | ID: mdl-29694495
Costus spiralis is a Brazilian native plant used in popular medicine, but the safety of this therapeutic use needs investigation. So, the aim of this study was to evaluate the cytogenotoxic and antigenotoxic effects of C. spiralis leaves or stems aqueous extracts on Allium cepa root cells. Moreover, a phytochemical screening and an antioxidant and antifungal activities evaluation were performed. C. spiralis aqueous extracts presented cytotoxicity, but no mutagenicity was observed. When the antigenotoxicity was evaluated, C. spiralis leaves aqueous extract presented preventive and modulatory effects on A. cepa root cells, reducing the sodium azide cytogenotoxic effects. In contrast, C. spiralis stems aqueous extract enhanced the sodium azide cytogenotoxicity in some conditions. The phytochemical screening revealed the presence of phenolic compounds in C. spiralis. When total phenolic content was determined, the leaves presented 73% more phenolic content than stems. Corroborating this data, C. spiralis leaves antioxidant potential was 30% higher than C. spiralis stems. However, these extracts did not present antifungal activity against Candida spp. In conclusion, empirical utilization of C. spiralis aqueous extracts should be avoided. Moreover, the cytotoxic effect of C. spiralis leaves and stems can play an important role in anticancer therapy and must be deeply studied.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Extractos Vegetales / Tallos de la Planta / Hojas de la Planta / Antifúngicos / Antioxidantes País/Región como asunto: America do sul / Brasil Idioma: En Revista: An Acad Bras Cienc Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Extractos Vegetales / Tallos de la Planta / Hojas de la Planta / Antifúngicos / Antioxidantes País/Región como asunto: America do sul / Brasil Idioma: En Revista: An Acad Bras Cienc Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Brasil