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Stable long-term BCI-enabled communication in ALS and locked-in syndrome using LFP signals.
Milekovic, Tomislav; Sarma, Anish A; Bacher, Daniel; Simeral, John D; Saab, Jad; Pandarinath, Chethan; Sorice, Brittany L; Blabe, Christine; Oakley, Erin M; Tringale, Kathryn R; Eskandar, Emad; Cash, Sydney S; Henderson, Jaimie M; Shenoy, Krishna V; Donoghue, John P; Hochberg, Leigh R.
Afiliación
  • Milekovic T; Department of Neuroscience, Brown University , Providence, Rhode Island.
  • Sarma AA; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.
  • Bacher D; Department of Fundamental Neuroscience, Faculty of Medicine, University of Geneva , Geneva , Switzerland.
  • Simeral JD; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.
  • Saab J; School of Engineering, Brown University , Providence, Rhode Island.
  • Pandarinath C; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development, Department of Veterans Affairs , Providence, Rhode Island.
  • Sorice BL; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.
  • Blabe C; School of Engineering, Brown University , Providence, Rhode Island.
  • Oakley EM; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.
  • Tringale KR; School of Engineering, Brown University , Providence, Rhode Island.
  • Eskandar E; Center for Neurorestoration and Neurotechnology, Rehabilitation Research & Development, Department of Veterans Affairs , Providence, Rhode Island.
  • Cash SS; Carney Institute for Brain Science, Brown University , Providence, Rhode Island.
  • Henderson JM; School of Engineering, Brown University , Providence, Rhode Island.
  • Shenoy KV; Department of Neurosurgery, Stanford University , Stanford, California.
  • Donoghue JP; Department of Electrical Engineering, Stanford University , Stanford, California.
  • Hochberg LR; Stanford Neurosciences Institute, Stanford University , Stanford, California.
J Neurophysiol ; 120(1): 343-360, 2018 07 01.
Article en En | MEDLINE | ID: mdl-29694279
Restoring communication for people with locked-in syndrome remains a challenging clinical problem without a reliable solution. Recent studies have shown that people with paralysis can use brain-computer interfaces (BCIs) based on intracortical spiking activity to efficiently type messages. However, due to neuronal signal instability, most intracortical BCIs have required frequent calibration and continuous assistance of skilled engineers to maintain performance. Here, an individual with locked-in syndrome due to brain stem stroke and an individual with tetraplegia secondary to amyotrophic lateral sclerosis (ALS) used a simple communication BCI based on intracortical local field potentials (LFPs) for 76 and 138 days, respectively, without recalibration and without significant loss of performance. BCI spelling rates of 3.07 and 6.88 correct characters/minute allowed the participants to type messages and write emails. Our results indicate that people with locked-in syndrome could soon use a slow but reliable LFP-based BCI for everyday communication without ongoing intervention from a technician or caregiver. NEW & NOTEWORTHY This study demonstrates, for the first time, stable repeated use of an intracortical brain-computer interface by people with tetraplegia over up to four and a half months. The approach uses local field potentials (LFPs), signals that may be more stable than neuronal action potentials, to decode participants' commands. Throughout the several months of evaluation, the decoder remained unchanged; thus no technical interventions were required to maintain consistent brain-computer interface operation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuadriplejía / Comunicación / Accidente Cerebrovascular / Interfaces Cerebro-Computador / Rehabilitación de Accidente Cerebrovascular / Esclerosis Amiotrófica Lateral Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: J Neurophysiol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cuadriplejía / Comunicación / Accidente Cerebrovascular / Interfaces Cerebro-Computador / Rehabilitación de Accidente Cerebrovascular / Esclerosis Amiotrófica Lateral Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Revista: J Neurophysiol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos