Your browser doesn't support javascript.
loading
Reciprocal Network between Cancer Stem-Like Cells and Macrophages Facilitates the Progression and Androgen Deprivation Therapy Resistance of Prostate Cancer.
Huang, Hai; Wang, Chao; Liu, Fei; Li, Hui-Zhen; Peng, Guang; Gao, Xu; Dong, Ke-Qin; Wang, Hong-Ru; Kong, De-Pei; Qu, Min; Dai, Li-He; Wang, Kai-Jian; Zhou, Zhe; Yang, Jun; Yang, Ze-Yu; Cheng, Yan-Qiong; Tian, Qin-Qin; Liu, Dan; Xu, Chuan-Liang; Xu, Dan-Feng; Cui, Xin-Gang; Sun, Ying-Hao.
Afiliación
  • Huang H; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Wang C; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Liu F; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Li HZ; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Peng G; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Gao X; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Dong KQ; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Wang HR; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Kong DP; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Qu M; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Dai LH; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Wang KJ; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Zhou Z; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Yang J; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Yang ZY; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Cheng YQ; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Tian QQ; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Liu D; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Xu CL; Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai, China.
  • Xu DF; Department of Urinary Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Cui XG; Department of Urinary Surgery, The Third Affiliated Hospital of Second Military Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai, China. sunyhsmmu@126.com cuixingang@smmu.edu.cn.
  • Sun YH; Department of Urinary Surgery, Gongli Hospital, Second Military Medical University, Shanghai, China.
Clin Cancer Res ; 24(18): 4612-4626, 2018 09 15.
Article en En | MEDLINE | ID: mdl-29691294
Purpose: Cancer stem-like cells (CSC) contribute to the progression and androgen deprivation therapy (ADT) resistance of prostate cancer. As CSCs depend on their specific niche, including tumor-associated macrophages (TAM), elucidating the network between CSCs and TAMs may help to effectively inhibit the progression and ADT resistance of prostate cancer.Experimental Design: The underlying intracellular mechanism that sustains the stem-like characteristics of CSCs in prostate cancer was assessed via RNA sequencing, co-immunoprecipitation, chromatin immunoprecipitation, and other assays. A coculture system and cytokine antibody arrays were used to examine the interaction network between CSCs and TAMs. In addition, an orthotopic prostate cancer model was established to evaluate the in vivo effects of the combined targeting of CSCs and their interaction with TAMs on ADT resistance.Results: Autophagy-related gene 7 (ATG7) facilitated the transcription of OCT4 via ß-catenin, which binds to the OCT4 promoter, promoting CSC characteristics in prostate cancer, including self-renewal, tumor initiation, and drug resistance. In addition, CSCs remodeled their specific niche by educating monocytes/macrophages toward TAMs, and the CSC-educated TAMs reciprocally promoted the stem-like properties of CSCs, progression and ADT resistance of prostate cancer via IL6/STAT3. Furthermore, the combined targeting of CSCs and their interaction with TAMs by inhibiting ATG7/OCT4 and IL6 receptor effectively ameliorated ADT resistance in an orthotopic prostate cancer model.Conclusions: Targeting CSCs and their niche may prove to be a more powerful strategy than targeting CSCs alone, providing a rational approach to ameliorating ADT resistance in prostate cancer. Clin Cancer Res; 24(18); 4612-26. ©2018 AACR.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Células Madre Neoplásicas / Resistencia a Antineoplásicos / Antagonistas de Andrógenos Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Células Madre Neoplásicas / Resistencia a Antineoplásicos / Antagonistas de Andrógenos Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Humans / Male / Middle aged Idioma: En Revista: Clin Cancer Res Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos