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Evaluating the utility of autoantibodies for disease activity and relapse in giant cell arteritis.
Kuret, T; Lakota, K; Hocevar, A; Burja, B; Cucnik, S; Sodin-Semrl, S.
Afiliación
  • Kuret T; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Lakota K; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Hocevar A; Faculty of Mathematics, Natural Science and Information Technologies, University of Primorska, Koper, Slovenia.
  • Burja B; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Cucnik S; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  • Sodin-Semrl S; Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
J Biol Regul Homeost Agents ; 32(2): 313-319, 2018.
Article en En | MEDLINE | ID: mdl-29685012
In patients with giant cell arteritis (GCA), autoantibodies against cytoskeletal elements, cardiolipin, neutrophil cytoplasmic antigens, ferritin, endothelial and smooth muscle cells have been reported, however no updated reviews are available evaluating their clinical utility. Methodology of detection is important, especially for quantitative assays, e.g. enzyme-linked immunoassays and multiplex beadbased immunoassays, while semiquantitative assays contribute valuable data on isoforms, epitope mapping and cellular localization. Most studies to date reporting on antiphospholipid antibodies in GCA have focused on anti-cardiolipin antibodies (aCL), while the highest prevalence of autoantibodies in GCA patients was reported for the anti-N-terminal peptides of the ferritin heavy chain (92%). Antineutrophil cytoplasmic antibodies were shown to be present in only a small percentage of GCA patients, decreasing after therapy, however in combination with aCL and antibodies against peptides of N-terminal ferritin heavy chain, they could represent an added value in detecting relapse in GCA patients.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Arteritis de Células Gigantes Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Autoanticuerpos / Arteritis de Células Gigantes Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Eslovenia Pais de publicación: Italia