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Antioxidant effects of Lycium barbarum polysaccharides on photoreceptor degeneration in the light-exposed mouse retina.
Tang, Liujiu; Bao, Shuyin; Du, Yu; Jiang, Zengyan; Wuliji, A O; Ren, Xiang; Zhang, Chenghong; Chu, Haiying; Kong, Li; Ma, Haiying.
Afiliación
  • Tang L; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Bao S; Inner Mongolia University for Nationalities, 028300, Tongliao, Inner Mongolia, China.
  • Du Y; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Jiang Z; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Wuliji AO; Inner Mongolia University for Nationalities, 028300, Tongliao, Inner Mongolia, China.
  • Ren X; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Zhang C; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Chu H; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China.
  • Kong L; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China. Electronic address: Kongli@dlmedu.edu.cn.
  • Ma H; Department of Histoembryology of Dalian Medical University, 116044, Dalian, Liaoning, China. Electronic address: hyma20060602@aliyun.com.
Biomed Pharmacother ; 103: 829-837, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29684862
We assessed the neuroprotective effects of Lycium barbarum Polysaccharides (LBP) on photoreceptor degeneration and the mechanisms involved in oxidative stress in light-exposed mouse retinas. Mice were given a gavage of LBP (150 mg/kg or 300 mg/kg) or phosphate buffered saline (PBS) for 7 days before exposure to light (5000 lx for 24 h). We found that LBP significantly improved the electroretinography (ERG) amplitudes of the a- and b-waves that had been attenuated by light exposure. In addition, changes caused by light exposure including photoreceptor cell loss, nuclear condensation, an increased number of mitochondria vacuoles, outer membrane disc swelling and cristae fractures were distinctly ameliorated by LBP. LBP treatment also significantly prevented the generation of reactive oxygen species (ROS) compared with PBS treatment. The levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and thioredoxin reductase (TrxR1) mRNA were decreased in PBS-treated mice compared with controls but increased remarkably in LBP-treated mice. The mRNA levels of the DNA repair gene Poly (ADP-ribose) polymerase (PARP14) was increased in PBS-treated mice but decreased significantly in the LBP-treated mice. Our findings indicate that pretreatment with LBP effectively protected photoreceptor cells against light-induced retinal damage probably through the up-regulation of the antioxidative genes Nrf2 and TrxR1, the elimination of oxygen free radicals, and the subsequent reduction in the mitochondrial reaction to oxidative stress and enhancement in antioxidant capacity. In addition, the decreased level of PARP14 mRNA in LBP-treated mice also indicated a protective effect of LBP on delaying photoreceptor in the light-damaged retina.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Luminosa / Degeneración Retiniana / Medicamentos Herbarios Chinos / Células Fotorreceptoras de Vertebrados / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estimulación Luminosa / Degeneración Retiniana / Medicamentos Herbarios Chinos / Células Fotorreceptoras de Vertebrados / Antioxidantes Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Biomed Pharmacother Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia