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JC Virus-DNA Detection Is Associated with CD8 Effector Accumulation in Peripheral Blood of Patients with Multiple Sclerosis under Natalizumab Treatment, Independently from JC Virus Serostatus.
Zingaropoli, Maria A; Iannetta, Marco; Pontecorvo, Simona; Anzivino, Elena; Prezioso, Carla; Rodio, Donatella Maria; Morreale, Manuela; D'Abramo, Alessandra; Oliva, Alessandra; Lichtner, Miriam; Cortese, Antonio; Frontoni, Marco; Pietropaolo, Valeria; Francia, Ada; Mastroianni, Claudio M; Vullo, Vincenzo; Ciardi, Maria R.
Afiliación
  • Zingaropoli MA; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Iannetta M; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Pontecorvo S; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
  • Anzivino E; Department of Neurology and Psychiatry, Multiple Sclerosis Center, Sapienza University, Rome, Italy.
  • Prezioso C; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Rodio DM; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Morreale M; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • D'Abramo A; Department of Medical and Surgical Sciences and Biotechnology, Neurovascular Diagnosis Unit, Section of Neurology, Sapienza University, Rome, Italy.
  • Oliva A; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Lichtner M; National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Rome, Italy.
  • Cortese A; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Frontoni M; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Pietropaolo V; Department of Neurology and Psychiatry, Multiple Sclerosis Center, Sapienza University, Rome, Italy.
  • Francia A; Department of Neurology and Psychiatry, Multiple Sclerosis Center, Sapienza University, Rome, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
  • Vullo V; Department of Neurology and Psychiatry, Multiple Sclerosis Center, Sapienza University, Rome, Italy.
  • Ciardi MR; Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
Biomed Res Int ; 2018: 5297980, 2018.
Article en En | MEDLINE | ID: mdl-29682547
Although natalizumab (anti-α4 integrin) represents an effective therapy for relapsing remitting multiple sclerosis (RRMS), it is associated with an increased risk of developing progressive multifocal leukoencephalopathy (PML), caused by the polyomavirus JC (JCV). The aim of this study was to explore natalizumab-induced phenotypic changes in peripheral blood T-lymphocytes and their relationship with JCV reactivation. Forty-four patients affected by RRMS were enrolled. Blood and urine samples were classified according to natalizumab infusion number: 0 (N0), 1-12 (N12), 13-24 (N24), 25-36 (N36), and over 36 (N > 36) infusions. JCV-DNA was detected in plasma and urine. T-lymphocyte phenotype was evaluated with flow cytometry. JCV serostatus was assessed. Ten healthy donors (HD), whose ages and sexes matched with the RRMS patients of the N0 group, were enrolled. CD8 effector (CD8 E) percentages were increased in natalizumab treated patients with detectable JCV-DNA in plasma or urine compared to JCV-DNA negative patients (JCV-) (p < 0.01 and p < 0.001, resp.). Patients with CD8 E percentages above 10.4% tended to show detectable JCV-DNA in plasma and/or urine (ROC curve p = 0.001). The CD8 E was increased when JCV-DNA was detectable in plasma or urine, independently from JCV serology, for N12 and N24 groups (p < 0.01). As long as PML can affect RRMS patients under natalizumab treatment with a negative JCV serology, the assessment of CD8 E could help in the evaluation of JCV reactivation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Viral / Virus JC / Linfocitos T CD8-positivos / Esclerosis Múltiple Recurrente-Remitente / Natalizumab Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN Viral / Virus JC / Linfocitos T CD8-positivos / Esclerosis Múltiple Recurrente-Remitente / Natalizumab Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Res Int Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos