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Human Pharmacological Conditioning of the Immune and Endocrine System: Challenges and Opportunities.
Tekampe, Judith; van Middendorp, Henriët; Sweep, Fred C G J; Roerink, Sean H P P; Hermus, Ad R M M; Evers, Andrea W M.
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  • Tekampe J; Health, Medical and Neuropsychology Unit, Faculty of Social and Behavioural Sciences, Institute of Psychology, Leiden University, Leiden, The Netherlands; Radboud University Medical Center, Nijmegen, The Netherlands.
  • van Middendorp H; Health, Medical and Neuropsychology Unit, Faculty of Social and Behavioural Sciences, Institute of Psychology, Leiden University, Leiden, The Netherlands; Radboud University Medical Center, Nijmegen, The Netherlands.
  • Sweep FCGJ; Radboud University Medical Center, Nijmegen, The Netherlands.
  • Roerink SHPP; Radboud University Medical Center, Nijmegen, The Netherlands.
  • Hermus ARMM; Radboud University Medical Center, Nijmegen, The Netherlands.
  • Evers AWM; Health, Medical and Neuropsychology Unit, Faculty of Social and Behavioural Sciences, Institute of Psychology, Leiden University, Leiden, The Netherlands; Radboud University Medical Center, Nijmegen, The Netherlands; Leiden University Medical Center, Leiden, The Netherlands. Electronic address: a.ev
Int Rev Neurobiol ; 138: 61-80, 2018.
Article en En | MEDLINE | ID: mdl-29681335
In this chapter, we review recent studies on conditioned pharmacological effects on immune and endocrine responses in humans, and discuss challenges and opportunities for bringing these effects into clinical practice. By altering physiological mechanisms in part independent of pharmacological agents, pharmacological conditioning has high clinical relevance, as illustrated in some patient studies. Methodological challenges for further investigation include broadening the spectrum of opportunities for conditioned pharmacological effects, by investigating conditioning of substances that have not or not often been used before (e.g., corticosteroids) and unraveling mechanisms by which pharmacological responses become conditioned, thereby identifying characteristics that make conditioning designs effective. As an opportunity to optimize external validity, we introduce a design in which the potential of pharmacological conditioning can be pretested in the laboratory. The feasibility of this design is demonstrated by a pilot study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efecto Placebo / Terapia de Inmunosupresión / Condicionamiento Clásico / Sistema Endocrino / Sistema Inmunológico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int Rev Neurobiol Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efecto Placebo / Terapia de Inmunosupresión / Condicionamiento Clásico / Sistema Endocrino / Sistema Inmunológico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Int Rev Neurobiol Año: 2018 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Estados Unidos