The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-&#954;B-mediated NLRP3 inflammasome.

Mao, Xiying; Pan, Ting; Shen, Han; Xi, Huiyu; Yuan, Songtao; Liu, Qinghuai

The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF-κB-mediated NLRP3 inflammasome.

Mao, Xiying; Pan, Ting; Shen, Han; Xi, Huiyu; Yuan, Songtao; Liu, Qinghuai.

Afiliación

Mao X; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Pan T; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Shen H; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Xi H; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Yuan S; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address: yuansongtao@vip.163.com.
Liu Q; Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China. Electronic address: liuqh@njmu.edu.cn.

Biomed Pharmacother ; 103: 517-523, 2018 Jul.

Article en En | MEDLINE | ID: mdl-29677537

Asunto(s)

Yodatos/toxicidad; Células Madre Mesenquimatosas/metabolismo; FN-kappa B/metabolismo; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Epitelio Pigmentado de la Retina/fisiología; Muerte Celular/efectos de los fármacos; Muerte Celular/fisiología; Línea Celular; Técnicas de Cocultivo; Humanos; Inflamasomas/metabolismo; Epitelio Pigmentado de la Retina/efectos de los fármacos; Epitelio Pigmentado de la Retina/patología

Palabras clave

Age-Related macular degeneration; Caspase; Inflammasome; Mesenchymal stem cell; NF-κB pathway; Retinal pigment epithelium

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Epitelio Pigmentado de la Retina / Células Madre Mesenquimatosas / Proteína con Dominio Pirina 3 de la Familia NLR / Yodatos Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia

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