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Oncological outcomes of IBD-associated versus sporadic colorectal cancer in modern era: a matched case-control study.
Thicoïpé, Antoine; Laharie, David; Smith, Denis; Chabrun, Edouard; Rullier, Anne; Poullenot, Florian; Rullier, Eric; Denost, Quentin.
Afiliación
  • Thicoïpé A; CHU of Bordeaux, Colorectal Unit, Department of Surgery, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Laharie D; CHU of Bordeaux, Department of Gastroenterology, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Smith D; CHU of Bordeaux, Department of Oncology, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Chabrun E; CHU of Bordeaux, Department of Gastroenterology, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Rullier A; CHU of Bordeaux, Department of Pathology, Pellegrin Hospital, University of Bordeaux, Bordeaux, France.
  • Poullenot F; CHU of Bordeaux, Department of Gastroenterology, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Rullier E; CHU of Bordeaux, Colorectal Unit, Department of Surgery, Magellan Hospital, University of Bordeaux, Bordeaux, France.
  • Denost Q; CHU of Bordeaux, Colorectal Unit, Department of Surgery, Magellan Hospital, University of Bordeaux, Bordeaux, France. quentin.denost@chu-bordeaux.fr.
Int J Colorectal Dis ; 33(7): 963-966, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29675590
AIM: Inflammatory bowel diseases (IBD) are associated with an increased risk for colorectal cancer (CRC). However and despite significant advances in the management of IBD and CRC, the prognosis of IBD-related CRC (IBD-CRC) remains controversial. The aim of the present case-control study was to compare the prognosis of IBD-CRC to sporadic CRC. METHODS: Consecutive patients operated for IBD-CRC from 2004 to 2014 were recruited and matched with sporadic CRC (ratio 3:1) from the same center. Matching was performed on gender, tumor stage, and location and period of surgery. Endpoints were postoperative morbidity (Dindo-Clavien III-V), quality of surgery, and long-term oncological outcomes. RESULTS: Among 1498 CRC patients operated during the study period, 21 patients were identified with IBD-CRC and matched to 63 patients with sporadic CRC (S-CRC). Patients with IBD-CRC were significantly younger (p < 0.001), had multifocal lesions more frequently (p = 0.04), and undergone abdominoperineal excision and coloproctectomy more often (p = 0.001). Postoperative morbidity was not significantly different between the two groups (25 vs. 14%; p = 0.309), as well as the rate of R0 resection (86 vs. 95%; p = 0.162). Five-year disease-free and overall survival were 71 and 81% in patients with IBD-CRC and 69% (p = 0.801) and 78% (p = 0.845) in those with S-CRC, respectively. CONCLUSION: In a case-control study of patients operated for CRC within the last decade, the prognosis of cancer associated with IBD is similar to sporadic cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Enfermedades Inflamatorias del Intestino Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Int J Colorectal Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Enfermedades Inflamatorias del Intestino Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Humans / Middle aged Idioma: En Revista: Int J Colorectal Dis Asunto de la revista: GASTROENTEROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Alemania