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Site-selective 18F fluorination of unactivated C-H bonds mediated by a manganese porphyrin.
Liu, Wei; Huang, Xiongyi; Placzek, Michael S; Krska, Shane W; McQuade, Paul; Hooker, Jacob M; Groves, John T.
Afiliación
  • Liu W; Department of Chemistry , Princeton University , Princeton , New Jersey 08544 , USA . Email: jtgroves@princeton.edu.
  • Huang X; Department of Chemistry , Princeton University , Princeton , New Jersey 08544 , USA . Email: jtgroves@princeton.edu.
  • Placzek MS; Athinoula A. Martinos Center for Biomedical Imaging , Massachusetts General Hospital , Harvard Medical School , Charlestown , Massachusetts 02129 , USA . Email: hooker@nmr.mgh.harvard.edu.
  • Krska SW; Division of Nuclear Medicine and Molecular Imaging , Department of Radiology , Massachusetts General Hospital , Boston , Massachusetts 02114 , USA.
  • McQuade P; Department of Process Chemistry , Merck Research Laboratories , Rahway , New Jersey 07065 , USA.
  • Hooker JM; Imaging Research , Merck Research Laboratories , West Point , Pennsylvania 19486 , USA.
  • Groves JT; Athinoula A. Martinos Center for Biomedical Imaging , Massachusetts General Hospital , Harvard Medical School , Charlestown , Massachusetts 02129 , USA . Email: hooker@nmr.mgh.harvard.edu.
Chem Sci ; 9(5): 1168-1172, 2018 Feb 07.
Article en En | MEDLINE | ID: mdl-29675161
The first direct C-H 18F fluorination reaction of unactivated aliphatic sites using no-carrier-added [18F]fluoride is reported. Under the influence of a manganese porphyrin/iodosylbenzene system, a variety of unactivated aliphatic C-H bonds can be selectively converted to C-18F bonds. The mild conditions, broad substrate scope and generally inaccessible regiochemistry make this radio-fluorination a powerful alternate to established nucleophilic substitution for the preparation of 18F labeled radio tracers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Sci Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido