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Founder-specific inbreeding depression affects racing performance in Thoroughbred horses.
Todd, Evelyn T; Ho, Simon Y W; Thomson, Peter C; Ang, Rachel A; Velie, Brandon D; Hamilton, Natasha A.
Afiliación
  • Todd ET; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia. evelyn.todd@sydney.edu.au.
  • Ho SYW; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
  • Thomson PC; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
  • Ang RA; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
  • Velie BD; Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, 75007, Uppsala, Sweden.
  • Hamilton NA; School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia.
Sci Rep ; 8(1): 6167, 2018 04 18.
Article en En | MEDLINE | ID: mdl-29670190
The Thoroughbred horse has played an important role in both sporting and economic aspects of society since the establishment of the breed in the 1700s. The extensive pedigree and phenotypic information available for the Thoroughbred horse population provides a unique opportunity to examine the effects of 300 years of selective breeding on genetic load. By analysing the relationship between inbreeding and racing performance of 135,572 individuals, we found that selective breeding has not efficiently alleviated the Australian Thoroughbred population of its genetic load. However, we found evidence for purging in the population that might have improved racing performance over time. Over 80% of inbreeding in the contemporary population is accounted for by a small number of ancestors from the foundation of the breed. Inbreeding to these ancestors has variable effects on fitness, demonstrating that an understanding of the distribution of genetic load is important in improving the phenotypic value of a population in the future. Our findings hold value not only for Thoroughbred and other domestic breeds, but also for small and endangered populations where such comprehensive information is not available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efecto Fundador / Rendimiento Atlético / Depresión Endogámica / Caballos / Endogamia Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Efecto Fundador / Rendimiento Atlético / Depresión Endogámica / Caballos / Endogamia Tipo de estudio: Prognostic_studies Límite: Animals País/Región como asunto: Oceania Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido