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Osteopontin Levels in Human Milk Vary Across Countries and Within Lactation Period: Data From a Multicenter Study.
Bruun, Signe; Jacobsen, Lotte Neergaard; Ze, Xiaolei; Husby, Steffen; Ueno, Hiroshi M; Nojiri, Keisuke; Kobayashi, Shunjiro; Kwon, Jungil; Liu, Xihong; Yan, Shuyuan; Yang, Jiyeon; Zachariassen, Gitte; Chen, Liang; Zhou, Wei; Christensen, Brian; Sørensen, Esben S.
Afiliación
  • Bruun S; Strategic Business Unit Pediatric, Arla Foods Ingredients Group P/S, Viby J.
  • Jacobsen LN; Hans Christian Andersen Children's Hospital, Odense University Hospital.
  • Ze X; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark.
  • Husby S; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Ueno HM; Strategic Business Unit Pediatric, Arla Foods Ingredients Group P/S, Viby J.
  • Nojiri K; Health Science Department, Biostime (Guangzhou) Health Products Ltd, Guangzhou, China.
  • Kobayashi S; Hans Christian Andersen Children's Hospital, Odense University Hospital.
  • Kwon J; Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark.
  • Liu X; OPEN, Odense Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.
  • Yan S; Research and Development Department, Bean Stalk Snow Co, Ltd, Kawagoe, Japan.
  • Yang J; Research and Development Department, Bean Stalk Snow Co, Ltd, Kawagoe, Japan.
  • Zachariassen G; Research and Development Department, Bean Stalk Snow Co, Ltd, Kawagoe, Japan.
  • Chen L; Human Milk Research and Development Department, Maeil Innovation Center, Maeil Dairies Co, Ltd., Gyeonggi, Republic of Korea.
  • Zhou W; Department of Clinical Nutrition, Guangzhou Women and Children's Medical Centre, Guangzhou.
  • Christensen B; Child Health Care Center, Changsha Hospital for Maternal and Child Health Care, Changsha.
  • Sørensen ES; Human Milk Research and Development Department, Maeil Innovation Center, Maeil Dairies Co, Ltd., Gyeonggi, Republic of Korea.
J Pediatr Gastroenterol Nutr ; 67(2): 250-256, 2018 08.
Article en En | MEDLINE | ID: mdl-29668569
OBJECTIVES: Osteopontin (OPN) is a multifunctional protein expressed in many cell types, tissues and body fluids with the highest concentrations found in milk; significantly higher in human than in bovine milk. Intervention studies have indicated beneficial effects of supplementing infant formula with bovine OPN. In this multicenter study, we determined the OPN content in human milk samples from 629 Chinese, Danish, Japanese and Korean mothers. METHODS: At each study site, milk samples were collected and analyzed for OPN and protein concentration using ELISA and infrared spectroscopy, respectively. RESULTS: A total of 829 milk samples from 629 women were included. When delivering the first sample, mean maternal age was 31.4 years (SD 4.0), and median infant age was 13.4 weeks (interquartile range 4.6-17.9). The median OPN concentration varied across sites; from 99.7 mg/L in Danish, 185.0 mg/L in Japanese, 216.2 mg/L in Korean to 266.2 mg/L in Chinese mothers (P < 0.001), corresponding to 1.3%, 2.4%, 1.8% and 2.7% of the total protein content (OPN/protein%) (P < 0.05), respectively. Based on 75 Chinese and 33 Japanese mothers delivering more than 1 sample, multilevel (mixed model) linear regression analysis showed a decrease in OPN concentration with infant age (ß = (-11.3), 95% confidence interval (CI) = (-13.9) to (-8.8) and ß = (-2.1), 95% CI = (-3.2) to (-0.9), respectively). CONCLUSIONS: In this large multicenter study, we observed statistically significant differences in the OPN concentration and the OPN/protein% in human milk samples between countries. Based on mothers delivering more than 1 sample, a significant decrease within the lactation period was observed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia / Osteopontina / Leche Humana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Newborn País/Región como asunto: Asia / Europa Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lactancia / Osteopontina / Leche Humana Tipo de estudio: Clinical_trials Límite: Adult / Female / Humans / Male / Newborn País/Región como asunto: Asia / Europa Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos