UC-1V150, a potent TLR7 agonist capable of activating macrophages and potentiating mAb-mediated target cell deletion.

Dahal, L N; Gadd, A; Edwards, A D; Cragg, M S; Beers, S A

Dahal, L N; Gadd, A; Edwards, A D; Cragg, M S; Beers, S A.

Afiliación

Dahal LN; Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.
Gadd A; School of Biological Sciences, University of Reading, Whiteknights, Reading, UK.
Edwards AD; School of Pharmacy, University of Reading, Whiteknights, Reading, UK.
Cragg MS; Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.
Beers SA; Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, Southampton General Hospital, University of Southampton, Southampton, UK.

Scand J Immunol ; 87(6): e12666, 2018 Jun.

Article en En | MEDLINE | ID: mdl-29667229

RESUMEN

Toll-like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer. For this reason, over the last 2 decades, TLR and their associated signalling pathways have been targeted therapeutically to enhance innate and adaptive immunity. Several TLR ligands, both endogenous and synthetic are at various phases of clinical testing, and new ligands are continually emerging. Agonists of TLR7 are known immune response modifiers, simultaneously stimulating several cell types, resulting in immune cell activation and cytokine and chemokine release. The immune stimulating properties of the TLR7 agonist Imiquimod has also been exploited for use in the treatment of malignant superficial tumours of the skin. Here, we investigated a novel TLR7 agonist UC-1V150 and demonstrate it activates both human and mouse myeloid cells in vitro and in vivo, to deliver potent FcÎ³R-mediated engulfment of opsonized target cells.

Asunto(s)

Benzaldehídos/química; Benzaldehídos/farmacología; Factores Inmunológicos/farmacología; Activación de Macrófagos/efectos de los fármacos; Macrófagos/inmunología; Glicoproteínas de Membrana/agonistas; Fagocitosis/inmunología; Purinas/química; Purinas/farmacología; Receptor Toll-Like 7/agonistas; Aminoquinolinas/farmacología; Animales; Anticuerpos Monoclonales/inmunología; Células Cultivadas; Humanos; Imiquimod; Activación de Macrófagos/inmunología; Macrófagos/efectos de los fármacos; Ratones; Ratones Endogámicos C57BL; Fagocitosis/efectos de los fármacos; Receptores de IgG/biosíntesis

Palabras clave

Fc gamma receptor; macrophage; target cell deletion; toll-like receptors

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fagocitosis / Purinas / Benzaldehídos / Glicoproteínas de Membrana / Receptor Toll-Like 7 / Factores Inmunológicos / Activación de Macrófagos / Macrófagos Límite: Animals / Humans Idioma: En Revista: Scand J Immunol Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido

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