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Serum 25-hydroxyvitamin D levels throughout pregnancy: a longitudinal study in healthy and preeclamptic pregnant women.
Agudelo-Zapata, Yessica; Maldonado-Acosta, Luis Miguel; Sandoval-Alzate, Héctor Fabio; Poveda, Natalia Elvira; Garcés, María Fernanda; Cortés-Vásquez, Jonathan Alexander; Linares-Vaca, Andrés Felipe; Mancera-Rodríguez, Carlos Alejandro; Perea-Ariza, Shahar Alexandra; Ramírez-Iriarte, Karen Yuliana; Castro-Saldarriaga, Camilo Andrés; Arteaga-Diaz, Juan Manuel; Franco-Vega, Roberto; Ángel-Müller, Edith; Parada-Baños, Arturo José; Caminos, Jorge E.
Afiliación
  • Agudelo-Zapata Y; Division of EndocrinologyDepartment of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Maldonado-Acosta LM; Division of EndocrinologyDepartment of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Sandoval-Alzate HF; Department of Human NutritionSchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Poveda NE; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Garcés MF; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Cortés-Vásquez JA; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Linares-Vaca AF; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Mancera-Rodríguez CA; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Perea-Ariza SA; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Ramírez-Iriarte KY; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Castro-Saldarriaga CA; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Arteaga-Diaz JM; Division of EndocrinologyDepartment of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Franco-Vega R; Division of EndocrinologyDepartment of Internal Medicine, School of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Ángel-Müller E; Department of Obstetrics and GynecologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Parada-Baños AJ; Department of Obstetrics and GynecologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia.
  • Caminos JE; Department of PhysiologySchool of Medicine, Universidad Nacional de Colombia, Bogotá, Colombia jecaminosp@unal.edu.co.
Endocr Connect ; 7(5): 698-707, 2018 May.
Article en En | MEDLINE | ID: mdl-29666170
BACKGROUND: Worldwide there is a high prevalence of 25-hydroxyvitamin D (25OHD) deficiency and has been associated with adverse outcomes during pregnancy. OBJECTIVE: This is a nested, case-control study in a longitudinal cohort to compare the serum 25OHD levels and other biomarkers throughout pregnancy in a group of 20 preeclamptic women and 61 healthy pregnant women. An additional group of 29 healthy non-pregnant women were also studied during the two phases of the menstrual cycle. RESULTS: Mean 25OHD levels in non-pregnant women were 31.9 ng/mL and 34.9 ng/mL during follicular and luteal phase, respectively (P < 0.01). Mean serum 25OHD levels in healthy pregnant women were 26.5, 30.1 and 31.9 ng/mL, at first, second and third trimester, respectively (P < 0.001). The first trimester levels of 25OHD were lower than those of healthy non-pregnant women (P < 0.001), showing a significant recovery at third trimester. In the group of healthy pregnant women, the 25OHD levels were 25.7 ng/mL and 27.2 ng/mL at 3 and 6 months postpartum, respectively; both values were lower than those observed in the non-pregnant women (P < 0.001). In preeclamptic women, 25OHD serum levels were similar to those of healthy pregnant women; nevertheless, they remained almost unchanged throughout pregnancy. CONCLUSION: There were no significant differences between healthy and preeclamptic pregnant women in terms of 25OHD levels throughout the pregnancy. Serum 25OHD levels in non-pregnant women were higher during luteal phase compared with follicular phase. The 25OHD levels of non-pregnant women tended to be higher than those of pregnant women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Endocr Connect Año: 2018 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Endocr Connect Año: 2018 Tipo del documento: Article País de afiliación: Colombia Pais de publicación: Reino Unido