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A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression.
Shimanoe, C; Hachiya, T; Hara, M; Nishida, Y; Tanaka, K; Sutoh, Y; Shimizu, A; Hishida, A; Kawai, S; Okada, R; Tamura, T; Matsuo, K; Ito, H; Ozaki, E; Matsui, D; Ibusuki, R; Shimoshikiryo, I; Takashima, N; Kadota, A; Arisawa, K; Uemura, H; Suzuki, S; Watanabe, M; Kuriki, K; Endoh, K; Mikami, H; Nakamura, Y; Momozawa, Y; Kubo, M; Nakatochi, M; Naito, M; Wakai, K.
Afiliación
  • Shimanoe C; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
  • Hachiya T; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate, Japan.
  • Hara M; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
  • Nishida Y; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
  • Tanaka K; Department of Preventive Medicine, Faculty of Medicine, Saga University, Saga, Japan.
  • Sutoh Y; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate, Japan.
  • Shimizu A; Division of Biomedical Information Analysis, Iwate Tohoku Medical Megabank Organization, Disaster Reconstruction Center, Iwate Medical University, Iwate, Japan.
  • Hishida A; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Kawai S; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Okada R; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Tamura T; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.
  • Matsuo K; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Ito H; Division of Molecular and Clinical Epidemiology, Aichi Cancer Center Research Institute, Nagoya, Japan.
  • Ozaki E; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Matsui D; Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan.
  • Ibusuki R; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Shimoshikiryo I; Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
  • Takashima N; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.
  • Kadota A; Department of Public Health, Shiga University of Medical Science, Otsu, Japan.
  • Arisawa K; Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan.
  • Uemura H; Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Suzuki S; Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • Watanabe M; Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Kuriki K; Department of Public Health, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
  • Endoh K; Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • Mikami H; Laboratory of Public Health, Division of Nutritional Sciences, School of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan.
  • Nakamura Y; Division of Cancer Prevention and Epidemiology, Chiba Cancer Center, Chiba, Japan.
  • Momozawa Y; Division of Cancer Prevention and Epidemiology, Chiba Cancer Center, Chiba, Japan.
  • Kubo M; Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Nakatochi M; RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
  • Naito M; Statistical Analysis Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.
  • Wakai K; Department of Maxillofacial Functional Development, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Genes Brain Behav ; 18(2): e12481, 2019 02.
Article en En | MEDLINE | ID: mdl-29665250
Individuals use coping behaviors to deal with unpleasant daily events. Such behaviors can moderate or mediate the pathway between psychosocial stress and health-related outcomes. However, few studies have examined the associations between coping behaviors and genetic variants. We conducted a genome-wide association study (GWAS) on coping behaviors in 14088 participants aged 35 to 69 years as part of the Japan Multi-Institutional Collaborative Cohort Study. Five coping behaviors (emotional expression, emotional support seeking, positive reappraisal, problem solving and disengagement) were measured and analyzed. A GWAS analysis was performed using a mixed linear model adjusted for study area, age and sex. Variants with suggestive significance in the discovery phase (N = 6403) were further examined in the replication phase (N = 7685). We then combined variant-level association evidence into gene-level evidence using a gene-based analysis. The results showed a significant genetic contribution to emotional expression and disengagement, with an estimation that the 19.5% and 6.6% variance in the liability-scale was explained by common variants. In the discovery phase, 12 variants met suggestive significance (P < 1 × 10-6 ) for association with the coping behaviors and perceived stress. However, none of these associations were confirmed in the replication stage. In gene-based analysis, FBXO45, a gene with regulatory roles in synapse maturation, was significantly associated with emotional expression after multiple corrections (P < 3.1 × 10-6 ). In conclusion, our results showed the existence of up to 20% genetic contribution to coping behaviors. Moreover, our gene-based analysis using GWAS data suggests that genetic variations in FBXO45 are associated with emotional expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Adaptación Psicológica / Emoción Expresada / Proteínas F-Box Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genes Brain Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / GENETICA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo Genético / Adaptación Psicológica / Emoción Expresada / Proteínas F-Box Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Genes Brain Behav Asunto de la revista: CIENCIAS DO COMPORTAMENTO / GENETICA Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido